Topological transition on a conformal manifold for the quantum Ising model with a longer range interaction.

An attempt is made to show the topological transition on conformal manifold for quantum Ising model with longer range interaction. This model Hamiltonian system has different gapped phases with different topological indices and also different quantum critical lines depending on the presence and absence of the transverse field. We also present the central charge for the different regimes of the parameter space.

Critical scaling of a two-orbital topological model with extended neighboring couplings.

Extended-range models are the interesting systems, which has been widely used to understand the non-local properties of the fermions at quantum scale. We aim to study the interplay between criticality and extended range couplings under various symmetry constraints. Here, we consider a two orbital Bernevig-Hughes-Zhang model in one dimension with longer (finite neighbor) and long-range (infinite neighbor) couplings.

Density Functional Theory-Guided Photo-Triggered Anticancer Activity of Curcumin-Based Zinc(II) Complexes.

Photodynamic therapy (PDT) has evolved as a new therapeutic modality for cancer treatment with fewer side effects and drug resistance. Curcumin exhibits PDT activity, but its low bioavailability restricts its clinical application. Here, the bioavailability of curcumin was increased by its complex formation with the Zn(II) center.

Unconventional quantum criticality in a non-Hermitian extended Kitaev chain.

We investigate the nature of quantum criticality and topological phase transitions near the critical lines obtained for the extended Kitaev chain with next nearest neighbor hopping parameters and non-Hermitian chemical potential. We surprisingly find multiple gap-less points, the locations of which in the momentum space can change along the critical line unlike the Hermitian counterpart. The interesting simultaneous occurrences of vanishing and sign flipping behavior by real and imaginary components, respectively of the lowest excitation is observed near the topological phase transition.

Mixed state behavior of Hermitian and non-Hermitian topological models with extended couplings.

Geometric phase is an important tool to define the topology of the Hermitian and non-Hermitian systems. Besides, the range of coupling plays an important role in realizing higher topological indices and transition among them. With a motivation to understand the geometric phases for mixed states, we discuss finite temperature analysis of Hermitian and non-Hermitian topological models with extended range of couplings.

Physics of emergence beyond Berezinskii-Kosterlitz-Thouless transition for interacting topological quantum matter.

An attempt is made to find different emergent quantum phases for interacting topological state of quantum matter. Our study is based on the quantum field theoretical renormalization group (RG) calculations. The behaviour of the RG flow lines give the emergence of different quantum phases for non-interacting and interacting topological state of quantum matter.

Topological quantum criticality in non-Hermitian extended Kitaev chain.

An attempt is made to study the quantum criticality in non-Hermitian system with topological characterization. We use the zero mode solutions to characterize the topological phases and, criticality and also to construct the phase diagram. The Hermitian counterpart of the model Hamiltonian possess quite a few interesting features such as Majorana zero modes (MZMs) at criticality, unique topological phase transition on the critical line and hence these unique features are of an interest to study in the non-Hermitian case also.

A study of quantum Berezinskii-Kosterlitz-Thouless transition for parity-time symmetric quantum criticality.

The Berezinskii-Kosterlitz-Thouless (BKT) mechanism governs the critical behavior of a wide range of many-body systems. We show here that this phenomenon is not restricted to conventional many body system but also for the strongly correlated parity-time (PT) symmetry quantum criticality. We show explicitly behaviour of topological excitation for the real and imaginary part of the potential are different through the analysis of second order and third order renormalization group (RG).

Multi-critical topological transition at quantum criticality.

The investigation and characterization of topological quantum phase transition between gapless phases is one of the recent interest of research in topological states of matter. We consider transverse field Ising model with three spin interaction in one dimension and observe a topological transition between gapless phases on one of the critical lines of this model. We study the distinct nature of these gapless phases and show that they belong to different universality classes.

A Study of Interaction Effects and Quantum Berezinskii- Kosterlitz-Thouless Transition in the Kitaev Chain.

The physics of the topological state of matter is the second revolution in quantum mechanics. We study the effect of interactions on the topological quantum phase transition and the quantum Berezinskii-Kosterlitz-Thouless (QBKT) transition in topological state of a quantum many-body condensed matter system. We predict a topological quantum phase transition from topological superconducting phase to an insulating phase for the interacting Kitaev chain.

A safe and efficacious Pt(ii) anticancer prodrug: design, synthesis, in vitro efficacy, the role of carrier ligands and in vivo tumour growth inhibition.

Diaminocyclohexane-Pt(ii)-phenalenyl complexes (1 and 2) showed an appropriate balance between efficacy and toxicity. Compound 2 showed nearly two-fold higher tumour growth inhibition than oxaliplatin in a murine NSCLC tumour model, when a combined drug development approach was used. The fluorescent properties of phenalenone were utilized to understand the mechanistic details of the drug.

Drug-Triggered Self-Assembly of Linear Polymer into Nanoparticles for Simultaneous Delivery of Hydrophobic and Hydrophilic Drugs in Breast Cancer Cells.

Breast cancer is the most devastating disease among females globally. Conventional chemotherapeutic regimen relies on the use of highly cytotoxic drugs as monotherapy and combination therapy leading to severe side effects to the patients as collateral damage. Moreover, combining hydrophobic and hydrophilic drugs create erratic biodistribution and suboptimal medicinal outcome.

Quantization of geometric phase with integer and fractional topological characterization in a quantum Ising chain with long-range interaction.

An attempt is made to study and understand the behavior of quantization of geometric phase of a quantum Ising chain with long range interaction. We show the existence of integer and fractional topological characterization for this model Hamiltonian with different quantization condition and also the different quantized value of geometric phase. The quantum critical lines behave differently from the perspective of topological characterization.

Topological Quantum Phase Transition and Local Topological Order in a Strongly Interacting Light-Matter System.

An attempt is made to understand the topological quantum phase transition, emergence of relativistic modes and local topological order of light in a strongly interacting light-matter system. We study this system, in a one dimensional array of nonlinear cavities. Topological quantum phase transition occurs with massless excitation only for the finite detuning process.

Physics of Majorana modes in interacting helical liquid.

As an attempt to understand and search for the existence of Majorana zero mode, we study the topological quantum phase transition and also the nature of this transition in helical liquid system, which appears in different physical systems. We present Majorana-Ising transition along with the phase boundary in the presence of interaction. We show the appearance of Majorana mode under the renormalization of the parameters of the system and also the topological protection of it.

Transferability of different classical force fields for right and left handed α-helices constructed from enantiomeric amino acids.

Amino acids can form d and l enantiomers, of which the l enantiomer is abundant in nature. The naturally occurring l enantiomer has a greater preference for a right handed helical conformation, and the d enantiomer for a left handed helical conformation. The other conformations, that is, left handed helical conformations of the l enantiomers and right handed helical conformations of the d enantiomers, are not common.

Propensity of Self-Assembled Leucine-Lysine Diblock Copolymeric α-Helical Peptides To Remain in Parallel and Antiparallel Alignments in Water.

Molecular dynamics simulation study of α-helical diblock copolypeptides preassembled in parallel and antiparallel alignments in water are presented. The assembled peptide lamellar structures were not disrupted even after performing three-step simulation protocols. Primarily hydrogen bonds between peptide are responsible for the stability.

Laparoscopic cholecystectomy in patients with cardiac dysfunction.

Laparoscopic cholecystectomy remains the standard treatment for cholelithiasis. Ever increasing number of patients with myriad of medical illness is being treated by this technique. However, significant concern prevails among the surgical community regarding its safety in patients with cardiac co-morbidity.

Open port placement through the umbilical cicatrix.

Peritoneal access and creation of pneumoperitoneum are the key initial steps of laparoscopic surgery. This is commonly achieved by either introducing Veress needle or by gradual dissection of all the layers of the abdominal wall and then introducing a port under direct vision. The two techniques are extremely safe, but large outcome studies have found slightly increased complications with the Veress needle.

Ion-trap mass spectrometry unveils the presence of isomeric oligosaccharides in an analyte: stage-discriminated correlation of energy-resolved mass spectrometry.

Mass spectrometry, especially tandem mass spectrometry, has been widely used in the field of analytical sciences for handling biological and chemical samples. The technique resolves molecular and fragment ions based on the mass to charge ratio. Energy-resolved mass spectrometry (ERMS) further provides an activation energy-related factor in the dissociation reaction.

Perivascular epithelioid cell tumor (PEComa) of falciform ligament - an extremely rare tumor.

Primary tumor of falciform ligament is exceedingly uncommon. So far, seven cases of Perivascular Epithelioid Cell tumor (PECom), a recently described histological entity with characteristic perivascular tumor cell arrangement and expression of muscle and melanocytic marker by the cells, have been reported in literature. Here, we report a case of PEComa of falciform ligament, which presented with a huge abdominal lump.

High-yielding and controlled dissociation of glycosides producing B- and C-ion species under collision-induced dissociation MS/MS conditions and use in structural determination.

Collision-induced dissociation (CID) in mass spectrometry is a powerful technique with which to understand gas-phase chemical reactions. A mass spectrometer is used to carry out the reaction, isolation, and analysis. On the other hand, structural analysis of glycan structures is of extreme importance in the analysis of biomolecules, such as glycoproteins and glycolipids.