Publications by authors named "Sujing Zong"
Article Synopsis
- Inflammation and oxidative damage are linked to osteoarthritis progression, and Bardoxolone methyl (CDDO-Me), a synthetic compound, has potent anti-inflammatory and antioxidant properties.
- Research indicates that CDDO-Me can inhibit osteoclast formation and degradation of the extracellular matrix (ECM) by activating specific pathways while suppressing harmful ones.
- In experiments using a mouse model of osteoarthritis, CDDO-Me reduced cartilage loss and osteoclast numbers, highlighting its potential as a treatment for the disease.
Osteoclast (OC) abnormalities lead to many osteolytic diseases, such as osteoporosis, inflammatory bone erosion, and tumor-induced osteolysis. Exploring effective strategies to remediate OCs dysregulation is essential. FTY720, also known as fingolimod, has been approved for the treatment of multiple sclerosis and has anti-inflammatory and immunosuppressive effects.
View Article and Find Full Text PDFIndian hedgehog (Ihh) is an indispensable paracrine factor for proper tissue patterning, skeletogenesis, and cellular proliferation. Recent genetic studies have revealed critical roles of chondrocyte-derived Ihh in regulating chondrocyte proliferation, hypertrophy and cartilage ossification. However, the functions of Sp7-expressing cell-derived Ihh in osteoblast differentiation and bone formation remain unclear.
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