In the battle of survival: transcriptome analysis of hypopharyngeal gland of the Apis mellifera under temperature-stress.

Background: Temperature is one of the essential abiotic factors required for honey bee survival and pollination. Apart from its role as a major contributor to colony collapse disorder (CCD), it also affects honey bee physiology and behavior. Temperature-stress induces differential expression of genes related to protein synthesis and metabolic regulation, correlating with impaired gland function.

Oxidative Stress and Risk of Dementia in Older Patients with Depression: A Longitudinal Cohort Study Using Plasma Biomarkers.

: While depression is associated with an increased risk of Alzheimer's dementia (AD), traditional AD-related biomarkers, such as amyloid-beta, have shown limited predictive value for late-life depression. Oxidative stress has emerged as a potential indicator given its shared role in both depression and dementia. This study investigated the longitudinal relationship between oxidative stress biomarkers and risk of dementia in patients with depression.

Establishing cutoff values for visual amyloid positivity in [F]flutemetamol PET.

Background: This study aimed to establish the optimal cutoff values for visual amyloid positivity using standardized uptake value ratios (SUVRs) in [F]flutemetamol (FMM) positron emission tomography (PET) imaging. Given the variability in amyloid assessment, our goal was to determine cutoff values that enhance diagnostic accuracy and assist clinicians in reliably identifying amyloid positivity.

Results: The identified cutoff values for visual amyloid positivity were > 1.

Analysis of Changes in Viral Load and Inflammatory Cytokines, as Well as the Occurrence of Secondary Infections, in SFTS Patients Treated with Specific Treatments: A Prospective Multicenter Cohort Study.

Severe fever with thrombocytopenia syndrome (SFTS) is an acute febrile illness caused by the SFTS virus (SFTSV). We conducted this study to propose a scientific evidence-based treatment that can improve prognosis through changes in viral load and inflammatory cytokines according to the specific treatment of SFTS patients. This prospective and observational study was conducted at 14 tertiary referral hospitals, which are located in SFTS endemic areas in Korea, from 1 May 2018 to 31 October 2020.

Automated Measurement of Effective Radiation Dose by F-Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography.

Background/objectives: Calculating the radiation dose from CT in F-PET/CT examinations poses a significant challenge. The objective of this study is to develop a deep learning-based automated program that standardizes the measurement of radiation doses.

Methods: The torso CT was segmented into six distinct regions using TotalSegmentator.

A Phase 1 randomized trial of homologous and heterologous filovirus vaccines with a late booster dose.

Filoviruses, including Ebola, Marburg, Sudan, and Taï Forest viruses, are zoonotic pathogens that can cause severe viral hemorrhagic fever and death. Developing vaccines that provide durable, broad immunity against multiple filoviruses is a high global health priority. In this Phase 1 trial, we enrolled 60 healthy U.

DDQ-catalyzed oxidative α-allylation of isochromans under aerobic conditions.

The allylation of isochromans at the α-position aerobic DDQ (2,3-dichloro-5,6-dicyano-1,4-benzoquinone) catalysis is described. This process involves the DDQ oxidation of various isochromans under mild conditions to generate oxocarbenium intermediates, which are effectively stabilized in equilibration in the presence of acid before undergoing allylation. Molecular oxygen and -butyl nitrite are employed as an environmentally benign oxidant and mediator, respectively, in the catalytic cycle.

Evaluation of the cardiotoxicity of Echinochrome A using human induced pluripotent stem cell-derived cardiac organoids.

Echinochrome A (EchA), a marine-derived natural product, has shown promise in treating cardiovascular and inflammatory diseases due to its antioxidant and anti-inflammatory properties. However, its cardiac safety remains underexplored. In this study, we utilized human induced pluripotent stem cell-derived cardiac organoids (hCOs) to validate their ability to model the cardiac safety profile of EchA in a human-relevant system.

Visible-Light-Stimulated Optoelectronic Neuromorphic Transistor Based on Indium-Gallium-Zinc Oxide via BiTe Light Absorption Layer.

To emulate a visual perception system, a bismuth telluride (BiTe)/indium-gallium-zinc oxide (IGZO) heterostructure is introduced for optoelectronic neuromorphic transistors (ONTs). Amorphous IGZO is applied as a channel layer to exhibit low off-current, high mobility, and persistent photoconductivity, enabling light-stimulated neuromorphic characteristics. The atomic ratio of In/Ga/Zn was 9.

SERS-Based Aptamer Sensing Strategy for Diabetes Biomarker Detection.

Accurate detection of glucose and insulin is crucial for early diagnosis, classification, and timely prevention of diabetes. In this study, we present a novel surface-enhanced Raman scattering (SERS) aptasensor for glucose and insulin detection. The SERS aptasensor is composed of gold bipyramidal nanoparticles (Au BPs), SH-aptamer-methylene blue (MB), and thiolated polyethylene glycol (SH-PEG).

Odd-Numbered Agaro-Oligosaccharides Produced by α-Neoagaro-Oligosaccharide Hydrolase Exert Antioxidant Activity in Human Dermal Fibroblasts.

Agarases produce agar oligosaccharides with various structures exhibiting diverse physiological activities. α-Neoagaro-oligosaccharide hydrolase (α-NAOSH) specifically cleaves even-numbered neoagaro-oligosaccharides, producing 3,6-anhydro-l-galactose (l-AHG) and odd-numbered agaro-oligosaccharides (OAOSs). In this study, α-NAOSH from the agar-degrading marine bacterium JEA5 (Gaa117) was purified and characterized using an expression system to produce OAOSs and determine their bioactivity.

Overexpression of Chromatin Remodeling Factor SRG3 Down-Regulates IL1β-Expressing M1 Macrophages and IL17-Producing T Cells in Adipose Tissues.

The SWItch3-related gene (SRG3) is a core component of ATP-dependent SWI/SNF complexes, which are crucial for regulating immune cell development and function (e.g., macrophages and CD4 T cells), embryonic development, and non-immune cell differentiation.

Effect of Waste PET Fiber on the Mechanical Properties and Chloride Ion Penetration of Emergency Repair Concrete for Road Pavement.

This study evaluated the effects of adding waste PET fibers on the mechanical properties and chloride ion penetration of latex-modified ultra-rapid hardening cement concrete used for emergency road pavement repairs. The primary experimental variable was the content of waste PET fibers. The mechanical properties of the concrete were evaluated through compressive strength, flexural strength, and splitting tensile strength tests.

The Implications of Aging on Vascular Health.

Vascular aging encompasses structural and functional changes in the vasculature, significantly contributing to cardiovascular diseases, which are the leading cause of death globally. The incidence and prevalence of these diseases increase with age, with most morbidity and mortality attributed to myocardial infarction and stroke. Diagnosing and intervening in vascular aging while understanding the mechanisms behind age-induced vascular phenotypic and pathophysiological alterations offers the potential for delaying and preventing cardiovascular mortality in an aging population.

A Systematic Review and Narrative Synthesis of Strategies for Disaster Risk Reduction Education for People With Disabilities.

Aims: To identify the components and characteristics of disaster risk reduction education for people with disabilities and to explore the contents and results of disaster risk reduction education.

Design: A systematic review and narrative synthesis.

Review Methods: The review was conducted in accordance with Tawfik's guidelines and followed the reporting standards outlined in the Preferred Reporting Items for Systematic reviews and Meta-Analysis.

Virtual diagnosis of diabetic nephropathy using metabolomics in place of kidney biopsy: The DIAMOND study.

Aims: To explore the clinical factors and urinary metabolites that predict biopsy-confirmed diabetic nephropathy (DN) in patients with type 2 diabetes mellitus (T2DM).

Methods: Data from the medical records of 126 patients with T2DM who underwent kidney biopsy between January 2010 and October 2020 at a single-center were retrospectively reviewed to investigate the clinical factors that predict DN. Urine samples were collected to perform urine metabolomics in patients with T2DM divided by biopsy-confirmed DN, immunoglobulin A, and membranous nephropathy, and a control group of healthy participants.

The Use of Telehealth for People With Disabilities: A Systematic Literature Review and Narrative Synthesis.

Aims: To identify the use of telehealth for people with disabilities in community or primary care settings and to explore effective telehealth interventions for this group.

Design: Systematic literature review and narrative synthesis.

Data Sources: The literature search was conducted in January 2024 using five electronic databases including PubMed, EMBASE, CINAHL, Cochrane library and PsycINFO.

Association Between Perceived Noise Pollution and Sleep Quality: Findings from the 2018 Community Health Survey.

Objectives: This study aimed to investigate the potential relationship between sleep quality and perceived noise.

Methods: A cross-sectional study involving 185,246 adults (81,854 men and 103,392 women) participating in the 2018 Korea Community Health Survey (KCHS) was conducted. Subjective sleep quality was assessed using the Pittsburgh Sleep Quality Index (PSQI), while perceived noise pollutants were categorized into two groups: perceived noise pollution (n = 43,638) and perceived non-noise pollution (n = 141,608).

Postmortem-Derived Exosomal MicroRNA 486-5p as Potential Biomarkers for Ischemic Heart Disease Diagnosis.

Exosomes are nanovesicles 30-150 nm in diameter released extracellularly. Those isolated from human body fluids reflect the characteristics of their cells or tissues of origin. Exosomes carry extensive biological information from their parent cells and have significant potential as biomarkers for disease diagnosis and prognosis.

Correlation with Apoptosis Process through RNA-Seq Data Analysis of Hep3B Hepatocellular Carcinoma Cells Treated with Extract (GLE).

is a perennial herb found in coastal sand dunes throughout East Asia. This herb has been reported to have hepatoprotective, immunomodulatory, antioxidant, antibacterial, antifungal, anti-inflammatory, and anticancer activities. It may be effective against hepatocellular carcinoma (HCC).