The bacterial quorum sensing signal 2'-aminoacetophenone rewires immune cell bioenergetics through the Ppargc1a/Esrra axis to mediate tolerance to infection.

How bacterial pathogens exploit host metabolism to promote immune tolerance and persist in infected hosts remains elusive. To achieve this, we show that () a recalcitrant pathogen, utilizes the quorum sensing (QS) signal 2'-aminoacetophenone (2-AA). Here, we unveil how 2-AA-driven immune tolerization causes distinct metabolic perturbations in murine macrophages' mitochondrial respiration and bioenergetics.

Skeletal muscle mitochondrial dysfunction mediated by quorum-sensing transcription factor MvfR: reversing effects with anti-MvfR and mitochondrial-targeted compounds.

Unlabelled: Sepsis and chronic infections with , a leading "ESKAPE" bacterial pathogen, are associated with increased morbidity and mortality and skeletal muscle atrophy. The actions of this pathogen on skeletal muscle remain poorly understood. In skeletal muscle, mitochondria serve as a crucial energy source, which may be perturbed by infection.

Skeletal Muscle Mitochondrial Dysfunction Mediated by Quorum Sensing Transcription Factor MvfR: Reversing Effects with Anti-MvfR and Mitochondrial-Targeted Compounds.

Sepsis and chronic infections with a leading "ESKAPE" bacterial pathogen, are associated with increased morbidity and mortality and skeletal muscle atrophy. The actions of this pathogen on skeletal muscle remain poorly understood. In skeletal muscle, mitochondria serve as a crucial energy source, which may be perturbed by infection.

The Bacterial Quorum-Sensing Signal 2-Aminoacetophenone Rewires Immune Cell Bioenergetics through the PGC-1α/ERRα Axis to Mediate Tolerance to Infection.

How bacterial pathogens exploit host metabolism to promote immune tolerance and persist in infected hosts remains elusive. To achieve this, we show that Pseudomonas aeruginosa (PA), a recalcitrant pathogen, utilizes the quorum sensing (QS) signal 2-aminoacetophenone (2-AA). Here, we unveil how 2-AA-driven immune tolerization causes distinct metabolic perturbations in macrophages mitochondrial respiration and bioenergetics.

Sunlight-Driven Self-Cleaning Ultrafine Particulate Matter Filter with Antibacterial Activity.

Air pollution by particulate matter (PM) and airborne pathogens causes severe health problems in the human body. Presently, popular disposable air filters yield huge waste and have a fatal impact on the environment. Postuse cleaning of air filters also leads to secondary air and water pollution.

2D Materials Beyond Post-AI Era: Smart Fibers, Soft Robotics, and Single Atom Catalysts.

Recent consecutive discoveries of various 2D materials have triggered significant scientific and technological interests owing to their exceptional material properties, originally stemming from 2D confined geometry. Ever-expanding library of 2D materials can provide ideal solutions to critical challenges facing in current technological trend of the fourth industrial revolution. Moreover, chemical modification of 2D materials to customize their physical/chemical properties can satisfy the broad spectrum of different specific requirements across diverse application areas.

Improved Sheet Resistance of Nanofiber-Based Transparent Conducting Electrodes Using Silver Nanowires.

There is an increased need for research on flexible transparent electrodes (FTEs) because they are critical to next-generation electronic devices, such as wearable computers. In this study, highly conductive transparent conducting electrodes, based on polyvinylidene fluoride (PVDF) nanofiber webs treated with poly(3,4-ethylenedioxythiophene):poly(styrene sulfonate) (PEDOT:PSS) and silver nanowires (AgNWs), were successfully fabricated. Transparent conducting electrodes (TCEs) were obtained by a brush-painting process using different weight ratios of a AgNWs to PEDOT:PSS solution, and the surface, electrical, optical, and chemical properties, as well as the tensile strength of the samples, were determined.

Fabrication of Poly(3,4-ethylenedioxythiophene):Poly(styrenesulfonate)/Poly(vinylidene fluoride) Nanofiber-Web-Based Transparent Conducting Electrodes for Dye-Sensitized Photovoltaic Textiles.

In this work, poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate) (PEDOT:PSS)/poly(vinylidene fluoride) (PVDF) nanofiber-web-based transparent conducting electrodes (TCEs) were fabricated for use in dye-sensitized photovoltaic textiles. The PEDOT:PSS solution was mixed with dimethyl sulfoxide (DMSO) solvent, and the PEDOT:PSS/DMSO mixture was applied on the PVDF nanofiber web using a simple brush-painting technique to prepare ultrathin and -lightweight, highly transparent TCEs. When the PVDF nanofiber web was treated with a 3:7 PEDOT:PSS and DMSO mixture (P3D7 sample), it exhibited ∼84% transmittance at a wavelength of 550 nm with an average sheet resistance of ∼1.

Mass spectrometric analysis of cyclofenil and its metabolites in human urine.

Using gas chromatography/electron impact-mass spectrometry (GC/EI-MS) and high performance liquid chromatography with atmospheric pressure chemical ionization tandem mass spectrometry (HPLC/APCI-MS/MS), the structures of cyclofenil metabolites in human urine have been assigned. The hydroxyl metabolites liberated from the glucuronide conjugates after acid hydrolysis were characterized as the trimethylsilyl (O-TMS) derivatives using GC/MS. The conjugate glucuronide forms were detected without hydrolysis by HPLC/MS.