Hot-Melt Extrusion Drug Delivery System-Formulated Extracts Regulate Inflammation and Oxidative Stress in Lipopolysaccharide-Stimulated Macrophages.

contains valuable bioactive compounds, including astaxanthin, proteins, and fatty acids. Astaxanthin is known for its various health benefits, such as preserving the redox balance and reducing inflammation. However, its low stability and poor water solubility present challenges for various applications.

Synthesis of cytocompatible gum Arabic-encapsulated silver nitroprusside nanocomposites for inhibition of bacterial pathogens and food safety applications.

Silver nitroprusside (AgN) exhibits significant antibacterial activity; however, its inherent toxicity poses a major concern. This study synthesized AgN with enhanced antibacterial properties while minimizing toxicity. Gum Arabic (GA), a natural polysaccharide widely utilized in food and biomedical applications owing to its exceptional cytocompatibility, was selected for encapsulating AgN to mitigate toxicity while preserving or enhancing its biological activity.

Green Synthesis of Silver Nanoparticle Using Black Mulberry and Characterization, Phytochemical, and Bioactivity.

Synthesis of silver nanoparticles (AgNPs) using plant extracts has been proposed as a more advantageous and environmentally friendly alternative compared to existing physical/chemical methods. In this study, AgNPs were synthesized from silver nitrate using black mulberry (BM) extract. The biosynthesized AgNPs were characterized through an UV-visible spectrometer, X-ray diffraction, and transmission electron microscopy.

The Effect of Hot-Melt Extrusion of Mulberry Leaf on the Number of Active Compounds and Antioxidant Activity.

The aim of this study is to compare the functions of the physiologically active compounds of three types of mulberry leaf by cultivar, and to confirm the changes using hot-melt extrusion (HME-ML). The active components of mulberry leaf were analyzed using the HPLC system, and total phenolic content (TPC), total flavonoid content (TFC), and antioxidant activity were measured. Among the three varieties, the highest contents of rutin and isoquercetin were detected in Cheongil, of TPC in Cheongol, and of TFC in Cheongil.

Green Synthesis of Silver Nanoparticles (AgNPs) of Fabricated by Hot-Melt Extrusion Technology for Enhanced Antifungal Effects.

Green synthesis for synthesizing silver nanoparticles (AgNPs) has been suggested as an environmentally friendly alternative to conventional physical/chemical methods. In this study, we report the green synthesis of AgNPs using a hot-melt extrusion-processed Nakai (AGN) (HME-AGN) extract as a reducing agent to increase the water solubility of the active ingredient compared to the existing AGN. The mixture of the AGN extract and AgNO at about 420 nm could not confirm the formation of AgNPs.

An Enhanced Water Solubility and Stability of Anthocyanins in Mulberry Processed with Hot Melt Extrusion.

Mulberry fruits are rich sources of anthocyanins that exhibit beneficial biological activity. These anthocyanins become instable in an aqueous media, leading to their low bioavailability. In this study, a colloidal dispersion was produced by processing mulberry samples with hot-melt extrusion.

Biodegradable Nanoparticles-Loaded PLGA Microcapsule for the Enhanced Encapsulation Efficiency and Controlled Release of Hydrophilic Drug.

Recently, nano- and micro-particulate systems have been widely utilized to deliver pharmaceutical compounds to achieve enhanced therapeutic effects and reduced side effects. Poly (DL-lactide-co-glycolide) (PLGA), as one of the biodegradable polyesters, has been widely used to fabricate particulate systems because of advantages including controlled and sustained release, biodegradability, and biocompatibility. However, PLGA is known for low encapsulation efficiency (%) and insufficient controlled release of water-soluble drugs.