Publications by authors named "Sujhla Hamid"
Article Synopsis
- - Alkaline phosphatases (APs) are enzymes that have a role in various diseases, including cancer and Alzheimer's, and their overexpression is linked to disease progression.
- - The study tested three COX-2 inhibitors—nimesulide, piroxicam, and lornoxicam—for their ability to inhibit APs, finding nimesulide showed the most promise with strong binding and stability against the tissue nonspecific alkaline phosphatase (TNAP).
- - In laboratory tests, nimesulide and the other COX-2 inhibitors significantly reduced the activity of alkaline phosphatases in cancer cell lines, suggesting potential for these inhibitors in developing new cancer treatments.
This study is focused on the identification of thiazole-based inhibitors for the [Formula: see text]-glucosidase enzyme. For that purpose, (E)-2-(2-(arylmethylene)hydrazinyl)-4-arylthiazole derivatives were synthesized in two steps and characterized by various spectroscopic techniques. All derivatives and intermediates were evaluated for their in vitro [Formula: see text]-glucosidase inhibitory activity.
View Article and Find Full Text PDFA series of triarylimidazoles substituted with 2-arylindoles (4a-4j) were prepared and evaluated for their in vitro α-Glucosidase inhibition. α-Glucosidase inhibition assay displayed a new class of highly potent agents The new compounds showed significant α-glucosidase inhibitory activity as compared to the standard inhibitor acrabose. Structures of synthesized compounds were determined by using Mass spectrometry FT-IR, H NMR and C NMR.
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