Publications by authors named "Sujeong Geum"
The first total synthesis of (±)-jujuyane, a cyclooctanoid natural product, was accomplished from a (5 + 3) dimerization product of oxidopyrylium ylide that forms the cyclooctanoid core structure along with inherited stereochemical bias. Selective functional group modifications of the highly oxygenated dimeric structure, followed by the tactical functional group manipulation around the eight-membered carbocyclic core, enabled the total synthesis of (±)-jujuyane, which will serve a guide for future applications of oxidopyrylium dimers to the natural product total synthesis.
View Article and Find Full Text PDFTissue-based metabolic labeling of polysialic acids in living primary hippocampal neurons.
Proc Natl Acad Sci U S A
January 2015
Article Synopsis
- The modification of the neural cell-adhesion molecule (NCAM) with polysialic acid (PSA) is crucial for neuronal development, and this study explores a new method for labeling PSA-NCAM without causing neurotoxicity.
- A novel strategy was developed that incorporates an unnatural monosaccharide to better track the distribution of PSA-NCAM in hippocampal neurons, avoiding the problems seen in standard metabolic labeling techniques.
- Findings indicate that PSA-NCAM is continuously synthesized and primarily transported to growing neurites, rather than the cell body, providing insights for future research in chemical glycobiology.
A facile total synthesis of the reported structure for panaginsene through a trimethylenemethane (TMM) diyl mediated tandem cycloaddition reaction revealed that the spectroscopic data of the synthesized structure did not match with the data of the natural product. The total synthesis of the stereoisomer of the reported structure confirmed that the correct structure of panaginsene was the 11-epi stereoisomer of the originally proposed structure of panaginsene.
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