Comparison of Large Language Models in Diagnosis and Management of Challenging Clinical Cases.

Purpose: Compare large language models (LLMs) in analyzing and responding to a difficult series of ophthalmic cases.

Design: A comparative case series involving LLMs that met inclusion criteria tested on twenty difficult case studies posed in open-text format.

Methods: Fifteen LLMs accessible to ophthalmologists were tested against twenty case studies published in JAMA Ophthalmology.