prediction, molecular modeling, and dynamics studies on the targeted next-generation sequencing identified genes underlying congenital heart disease in Down syndrome patients.

Background: Individuals with Down syndrome (DS) have a 40%-60% chance of being born with congenital heart disease (CHD). This indicates that CHD in individuals with DS is not solely caused by trisomy 21, and there may be other genetic factors contributing to the development of CHD in these children. A study has identified variants in the specific genes that contribute to the pathogenesis of CHD in children with DS, isolated DS, and the CHD group.

An in silico analysis of the impact of POLE mutations on cladribine docking.

Objective: Polymerase ε exonuclease (POLE) is an enzyme involved in DNA replication and may be an attractive therapeutic target in various cancers. Here we sought to model the impact of specific POLE mutations on protein function. Due to the lack of a crystal structure, the tertiary structures of the wild type and four common mutants were modeled using I-Tasser server.

Estimation and correlation of procalcitonin in saliva and serum of chronic periodontitis patients before and after nonsurgical periodontal therapy: An analytical comparative study.

Background: Procalcitonin (ProCT) is an emerging inflammatory biomarker in bacterial infections. Few studies have reported raising salivary ProCT in periodontitis patients. Hence, the study aims to analyze and correlate the changes in saliva and serum ProCT in periodontitis patients before and after nonsurgical periodontal therapy.

Gestational age-specific centile charts for anthropometry at birth for South Indian infants.

Objective: To construct centile charts for birth weight, length and head circumference for infants born from 24 to 42 weeks of gestation and to compare with the other national and international growth charts.

Study Design: Observational descriptive study.

Subjects: All consecutively live born singleton infants from 24 to 42 weeks of gestation.