On-demand hyoscine butylbromide for the treatment of self-reported functional cramping abdominal pain.

Objective: Hyoscine butylbromide (HBB) has been used for 60 years to treat cramping abdominal pain, but scientific evidence to support on-demand use is limited. The aim of this study was to identify a meaningful efficacy end point that differentiates between the effects of HBB (20-100 mg/day) and placebo when used on demand.

Materials & Methods: 175 patients were treated in a randomized, double-blind, placebo-controlled, two-arm parallel group study.