Stereoselective synthesis of the northern hemisphere of the proposed structure of neaumycin B.

The stereoselective synthesis of the northern hemisphere (C-C) of the purported structure of the extremely potent anticancer natural product neaumycin B has been accomplished. Twelve out of nineteen asymmetry centers have been installed chemically. The key highlights of this synthesis include the Krische iridium catalyzed -diastereoselective carbonyl crotylation, the Crimmins aldol reaction, HWE olefination, CBS reduction, vanadium promoted stereoselective epoxidation, Evans methylation and spiroketalization.

Factors Associated With Psychological Outcomes Among Vaccinated and Unvaccinated Health Care Workers Against COVID-19 Infection in Bangladesh.

Background: Vaccination of healthcare workers (HCWs) is recommended during the COVID-19 pandemic to reduce the risk of infection for themselves and their patients, as well as to encourage their patients to get immunized. The present study aimed to investigate the psychological outcomes and associated factors among vaccinated and unvaccinated HCWs against COVID-19 infection in Bangladesh.

Methods: From March to August 2021, an online nationwide survey was conducted with a total of 2,038 Bangladeshi HCWs.