Publications by authors named "Sujan Dily Penchala"
Article Synopsis
- Snakebites impact over 5 million people annually, leading to over 100,000 deaths, with antivenom being the primary but problematic treatment due to its high cost and adverse effects.
- Unithiol, a chelating agent used for heavy metal poisoning, has shown promise in preventing tissue damage from certain viper species in small animal studies, prompting a clinical trial for snakebite treatment repurposing.
- The phase I trial will evaluate the safety of escalating doses of unithiol in 64 healthy volunteers, focusing on dose response, adverse effects, and pharmacokinetics, with the potential to offer a safer, orally-administered alternative to traditional antivenom.
Long-acting injectable antiretroviral (LA-ARV) drugs with low toxicity profiles and propensity for drug-drug interactions are a goal for future ARV regimens. C34-PEG-Chol is a novel cholesterol tagged LA HIV-fusion-inhibitor (FI). We assessed pre-clinical toxicology and first-in-human administration of C34-PEG-Chol.
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