[Association of gene polymorphisms of and and their interactions with community-acquired pneumonia in children].

Objectives: To investigate the association of single nucleotide polymorphisms (SNPs) of myeloid differentiation factor 88 () and Toll-like receptor adaptor molecule 1 () and their interactions with community-acquired pneumonia (CAP) in children.

Methods: Improved multiple ligase detection reaction assay was used for detecting the polymorphisms of nine tagging SNPs of the and genes in 375 children with CAP who attended the Department of Pediatrics of the Second Affiliated Hospital of Yan'an University Medical School from August 2015 to September 2017 and 306 healthy children who underwent physical examination. A logistic regression analysis was used to evaluate the association between the distribution of genotypes and their interactions with CAP in children.