An -functionalized molecular cage for selective potentiometric determination of creatinine.

Potentiometric ion-selective electrodes (ISEs), which rely on selective and lipophilic ionophores, are commonly employed in clinical diagnostics. However, there are very limited specific ionophores for the detection of creatinine, a critical biomarker for renal function assessment. In the present research, we designed and synthesized an -functionalized cage, which is able to selectively bind the creatininium cation ( = 8.