Publications by authors named "Sui Deng"
Background: The current landscape of acne therapeutics is notably lacking in targeted treatments, highlighting a critical need for the discovery of new drug targets to improve treatment outcomes.
Objectives: This study aims to investigate the connections between proteomics and genetics in relation to acne across extensive population cohorts, aspiring to identify innovative preventive and therapeutic approaches.
Methods: Employing a longitudinal cohort of 54,306 participants from the UK Biobank Pharmacological Proteomics Project (UKB-PPP), we performed an exhaustive evaluation of the associations between 2,923 serum proteins and acne risk.
Article Synopsis
- Observational studies suggest a connection between dyslipidemia (abnormal lipid levels) and atopic dermatitis (AD), but the exact causal relationship is unclear.
- Using Mendelian randomization, researchers analyzed genetic data to explore the impact of serum lipids on AD and identify potential medication targets.
- The study found that the PCSK9 gene significantly reduces the risk of AD, while no other lipid levels or treatments showed a link, suggesting PCSK9 could be a promising treatment for AD.