The optimal intervention for preventing physical restraints among older adults living in the nursing home: A systematic review.

Aim: This study aimed to evaluate the effectiveness of restraint reduction programs for nursing home care providers in enforcing physical restraint on residents and identify the best strategies for such programs.

Design: Systematic Review.

Methods: We searched for randomized controlled trials published until February 2021 for systematic review.

Association of Toll-like receptor 2 polymorphisms with gout.

Gout is the most common autoinflammatory arthritis characterized by elevated serum urate and recurrent attacks of intra-articular crystal deposition of monosodium urate (MSU) in tissues. The pathogenesis of gout has not been fully determined, although certain genetic factors are involved in the development of gout. Accumulated data suggested that MSU crystal-induced inflammation is a paradigm of innate immunity.

Screening of multiple myeloma by polyclonal rabbit anti-human plasmacytoma cell immunoglobulin.

Antibody-based immunotherapy has been effectively used for tumor treatment. However, to date, only a few tumor-associated antigens (TAAs) or therapeutic targets have been identified. Identification of more immunogenic antigens is essential for improvements in multiple myeloma (MM) diagnosis and therapy.

[SRY gene analysis for a case with sex reversal syndrome].

Objective: To investigate the molecular mechanism of sex reversal in a 46,XY female patient.

Methods: Clinical data was collected. Peripheral blood lymphocytes were cultured for G-banding chromosomal analysis and DNA extraction.

Identifying mRNAs bound by human RBMY protein in the testis.

Rbmy gene encodes a germ-cell specific nuclear RNA-binding protein and is involved in spermatogenesis. To further investigate the specific events of spermatogenesis in which Rbmy plays a role, the target mRNAs of human RBMY protein were isolated and identified. Through the isolating specific nucleic acids associated with proteins (SNAAP) technique, we isolated twenty potential target genes of human RBMY protein from the human testis in the present study.

DAZL binds to 3'UTR of Tex19.1 mRNAs and regulates Tex19.1 expression.

Spermatogenesis is a complex process subject to strict controls at both levels of transcription and translation. It has been proposed that DAZL protein binds to RNA in the cytoplasm of germ cells and controls spermatogenesis. In male mice, loss of Dazl results in numerous defects throughout the mitotic and meiotic process of germ cell development.

Effects of anti-leukemia drug Harringtonine on the levels of centromere proteins and gene expression of CenpB in L1210 cells.

In this study, we investigated the effects of the anti-leukemia drug Harringtonine (HT) on the levels of centromere proteins and gene expression of centromere protein CenpB in L1210 cells. The intensity of centromere fluorescence, shown by indirect immunofluorescence staining, decreased with HT treatment. Western blot showed that the anti-centromere antibody (ACA) serum used in this study recognized 8 proteins with different molecular weights: 140, 80, 70, 56, 37, 34, 32 and 17 kD.