Association between TRMT61B gene polymorphism and Wilms tumor susceptibility in Chinese children.

Background: Wilms tumor is among the most common pediatric malignant tumors. Although mA modification influences the structure and function of RNA and participates in tumorigenesis, the relationship between mA methyltransferase TRMT61B gene polymorphisms and Wilms tumor susceptibility is unclear.

Methods: We examined the relationship between TRMT61B gene rs4563180 G > C polymorphism (detected by TaqMan probe method) in 414 children with Wilms tumor and 1199 healthy controls.

Preparation and structure-function relationships of homogalacturonan-rich and rhamnogalacturonan-I rich pectin: A review.

Pectin has multiple functions and is widely used in the food industry. It is an acidic heteropolysaccharide found in most plants, mainly consisting of two regions: homogalacturonan (HG) and rhamnogalacturonan-I (RG-I). HG and RG-I rich pectin have unique structures and functional properties, which can be obtained through specific preparation methods.

Effects of hawthorn pectin and its oligomers on gut microbiota and metabolites in high-fat diet mice.

Pectin is an acidic heteropolysaccharide with natural, green, and inexpensive characteristics. Compared to polysaccharides, oligosaccharides are more easily utilized by the body, and the physiological function of hawthorn pectin oligosaccharides (POS) may vary depending on their degree of polymerization (DP). Therefore, we mainly studied the effects of hawthorn pectin (HP) and POS with different DP on gut microbiota disorders induced by high-fat diet (HFD).

Effects of TGase on the rheological behaviors, structural properties and molecular forces of cowpea protein isolate and cowpea albumin gels.

The effects of TGase on hardness, water holding capacity (WHC), molecular forces, structural properties, microstructure and rheological behaviors of TGase-induced cowpea protein isolate gel (T-CPIG) and cowpea albumin gel (T-CPAG) were investigated. TGase significantly increased the hardness of gels and the most stable three-dimensional network structures were formed by adding 20 U/g and 28 U/g. Not only the non-network structure proteins of gels and free sulfhydryl groups were fewer but also the β-fold and β-angle relative contents were higher than cowpea protein isolate (CPI) and cowpea albumin (CPA).

YTHDF3 rs7464 A > G polymorphism increases Chinese neuroblastoma risk: A multiple-center case-control study.

Neuroblastoma (NB), a rare childhood cancer originating in nerve tissue. YTHDF3, a member of the YTH domain protein family, is involved in RNA m6A modification and cancer progression. Polymorphisms in YTHDF3 may influence its expression and biological function.

gene polymorphisms increase Wilms tumor risk in Chinese girls.

Wilms tumor is a prevalent pediatric tumor influenced by various genetic factors. mA modification is a common nucleotide modification that plays a role in a variety of cancers. As a "reader", YTHDF3 is essential for recognizing mA modifications.

Gut microbiota combined with serum metabolites to reveal the effect of Morchella esculenta polysaccharides on lipid metabolism disordered in high-fat diet mice.

The ameliorating effects and mechanisms of Morchella esculenta polysaccharides (MEP-1) on lipid metabolism were investigated in high-fat diet (HFD) mice. The results showed that MEP-1 intervention significantly reduced serum TC, TG, LDL-C, and inflammatory factors (TNF-α, IL-1β and IL-6) in HFD mice in a dose-dependent manner, and high-dose (400 mg/kg/d) exhibited the most significant reductive effects. In addition, MEP-1 significantly recovered the gut microbiota disorders caused by HFD, especially decreasing the ratio of Firmicutes and Bacteroidetes (F/B) and increasing the dominant bacterial of Muribaculaceae_genus, Bacteroides, Alistipes and Enterococcus.

gene polymorphisms confer hepatoblastoma susceptibility: evidence from a seven-center case-control study.

N1-methyladenosine (mA) is a reversible epigenetic modification of RNAs. Aberrant mA modification levels due to dysregulation of mA regulators have been observed in multiple cancers. tRNA methyltransferase 10C (TRMT10C) can install mA in RNAs; however, its role in hepatoblastoma remains unknown.

RNF113A as a poor prognostic factor promotes metastasis and invasion of cervical cancer through miR197/PRP19/P38MAPK signaling pathway.

It has been discovered that aberrant expression of RNF113A plays a significant role in various diseases, including esophageal cancer, hepatocellular carcinoma, and X-linked trichothiodystrophy syndrome. Nevertheless, its functional implications in cervical cancer (CC) remain unclear. The objective of this study was to investigate the role of RNF113A in both the development and prognosis of CC.

LMO family gene polymorphisms and Wilms tumor susceptibility in Chinese children: a five-center case-control study.

Background: Wilms tumor is the most prevalent embryonal kidney malignancy in children worldwide. Previous genome-wide association study (GWAS) identified that LIM domain only 1 (LMO1) gene polymorphisms affected the susceptibility to develop certain tumor types. Apart from LMO1, the LMO gene family members also include LMO2-4, each of which has oncogenic potential.

Identification of a Novel Aflatoxin B-Degrading Strain, DDC-4, and Its Response Mechanisms to Aflatoxin B.

Aflatoxin B (AFB) contamination is a food safety issue threatening human health globally. Biodegradation is an effective method for overcoming this problem, and many microorganisms have been identified as AFB-degrading strains. However, the response mechanisms of these microbes to AFB remain unclear.

Vitexin-rhamnoside encapsulated with zein-pectin nanoparticles relieved high-fat diet induced lipid metabolism disorders in mice by altering the gut microbiota.

This study aimed to investigate the modulatory effects of Vitexin-rhamnoside (VR) and Zein-VR-pectin nanoparticles (VRN) on lipid metabolism disorders induced by high-fat diet (HFD). The ingestion of VR or VRN attenuated dyslipidemia and fat accumulation in HFD mice, and improved intestinal dysbiosis by regulating the relative abundance of dominant bacteria, alleviating chronic inflammation and hepatic injury in HFD mice. The intervention effect of VRN was significantly higher than that of VR.

Analysis of the current state of cervical cancer prevention awareness and its influencing factors among rural women in Luohe City.

The purpose of this cross-sectional study was to identify the current awareness about cervical cancer prevention among rural women in Luohe City as well as its potential influencing factors. Meanwhile, these data were expected to provide a theoretical basis for Luohe future cervical cancer prevention and therapy. Based on geographical distribution, 40 villages in Luohe City were randomly selected, and questionnaires were given to women in each village.

Transforming Dye Molecules into Electrochemical Allies: Direct Red 80 as a Dual-Functional Electrolyte Additive for Dendrite-Free Aqueous Zinc-Ion Batteries.

Despite the numerous advantages of abundant zinc resources, low redox potential, and affordability, aqueous zinc-ion batteries (AZIBs) currently face limitations due to dendritic growth and side reactions. This study explores the use of low-cost and efficient anionic dyes, specifically Direct Red 80 (DR80) as dual-functional electrolyte additives to enhance the electrochemical performance of AZIBs and facilitate the reuse of dye wastewater. Experimental and theory calculation results all demonstrate that the DR80 molecules readily adsorb onto the surface of the zinc anode, creating a stable and robust solid electrolyte interphase layer.

Distinctions in structure, rheology, antioxidation, and α-glucosidase inhibitory activity of β-glucans from different species.

To investigate the distinctions between β-glucans from different species, Lentinula edodes β-glucan (LG), yeast β-glucan (YG), and oat β-glucan (OG) were extracted with hot water and determined as β-d-glucopyranose form by HPLC and FT-IR analysis. The molecular weight (M) of LG, YG, and OG was 670 kDa, 341 kDa, and 66 kDa, respectively. Scanning electron microscopy exhibited different micro surfaces of three β-glucans and the relative crystallinity of YG was the highest (29.

Identification of hepatoblastoma susceptibility loci in the TRMT6 gene from a seven-center case-control study.

Hepatoblastoma, the most frequently diagnosed primary paediatric liver tumour, bears the lowest somatic mutation burden among paediatric neoplasms. Therefore, it is essential to identify pathogenic germline genetic variants, especially those in oncogenic genes, for this disease. The tRNA methyltransferase 6 noncatalytic subunit (TRMT6) forms a tRNA methyltransferase complex with TRMT61A to catalyse adenosine methylation at position N1 of RNAs.

Variations of quality and volatile components of morels (Morchella sextelata) during storage.

The postharvest senescence of morels was observed to be easily affected by temperature fluctuations. The objective of this study was to examine the influence of various storage temperatures on the postharvest senescence of morels. The study evaluated the variations of water content, respiration, nutrients substances, cell membrane permeability, and volatile compounds in morels stored at 20 °C and 4 °C.

rs4563180 G>C variant reduces hepatoblastoma risk: a case-control study of seven medical centers.

N-methyladenosine (mA) is an essential chemical modification of RNA. Dysregulation of RNA mA modification and mA-related regulators is detected in several adult tumors. Whether aberrant RNA mA modification is involved in hepatoblast carcinogenesis has not been reported.

TRMT6 gene rs236110 C > A polymorphism increases the risk of Wilms tumor.

tRNA methyltransferase 6 (TRMT6)is an enzyme catalyzing N1-methyladenosine, a reversible modification in RNA, including tRNA, mRNA, rRNA, and lncRNA. Increasing evidence has shown the implications of this post-transcriptional modification and its regulators in carcinogenesis. However, its roles in Wilms tumor haven't been reported.

gene polymorphisms and Wilms tumor susceptibility in Chinese children: A five-center case-control study.

Wilms tumor is the most common embryonal renal malignancy in children. WDR4 is an indispensable noncatalytic subunit of the RNA N7-methylguanosine (m7G) methyltransferase complex and plays an essential role in tumorigenesis. However, the relationship between polymorphisms in the gene and susceptibility to Wilms tumor remains to be fully investigated.

Variant rs8400 enhances ALKBH5 expression through disrupting miR-186 binding and promotes neuroblastoma progression.

Objective: AlkB homolog 5 (ALKBH5) has been proven to be closely related to tumors. However, the role and molecular mechanism of ALKBH5 in neuroblastomas have rarely been reported.

Methods: The potential functional single-nucleotide polymorphisms (SNPs) in were identified by National Center for Biotechnology Information (NCBI) dbSNP screening and SNPinfo software.