Higher objective responses by hepatic arterial infusion chemotherapy following atezolizumab and bevacizumab failure than when used as initial therapy in hepatocellular carcinoma: a retrospective study.

Purpose: Atezolizumab/bevacizumab (atezo-bev) is the first-line chemotherapy for patients with unresectable hepatocellular carcinoma (HCC). However, hepatic artery infusion chemotherapy (HAIC) can be used as an alternative. Our aim was to compare the prognosis of HAIC treatment between newly diagnosed patients and patients treated after failure of atezo-bev.

The Parathyroid Gland: An Overall Review of the Hidden Organ for Radiologists.

Parathyroid glands are small endocrine glands that regulate calcium metabolism by producing parathyroid hormone (PTH). These are located at the back of the thyroid gland. Typically, four glands comprise the parathyroid glands, although their numbers may vary among individuals.

Complete and Incomplete Alcohol Sclerotherapy for Treatment of Symptomatic Hepatic Cysts: Comparison of Volume Reduction and Clinical Outcomes.

: The purpose of this study was to compare the efficacy of incomplete alcohol sclerotherapy with complete treatment for hepatic cysts. : From 2005 to 2021, a total of 80 patients (19 males, 61 females; median age 65 years; age range, 42-86 years) who underwent alcohol sclerotherapy for symptomatic benign hepatic cysts were enrolled and retrospectively reviewed. Complete treatment was defined as injecting 25-33% of the aspirated cyst volume with alcohol in 2-3 cycles, with a maximum of 100 mL per cycle.

Role of Portosystemic Shunt and Portal Vein Stent in Managing Portal Hypertension Due to Hematological Diseases.

Introduction: Patients with hematological diseases experience complications related to portal hypertension, including life-threatening complications such as variceal bleeding.

Methods: We analyzed the prognosis of patients with hematological diseases and portal hypertension treated with transjugular intrahepatic portosystemic shunts (TIPS) or portal vein stents. We retrospectively assessed patients with hematological diseases and portal hypertension who had variceal bleeding.

Impregnation of Activated Carbon with Organic Phase-Change Material.

In this study, we developed a thermal storage medium comprising porous activated carbon filled with organic phase-change materials (PCMs) that utilizes the latent heat of phase-change to absorb heat during heating and release heat during cooling. For the activated carbon, we used both charcoal-based powdered activated carbon (250-350 mesh) and granular activated carbon. The organic phase-change materials used in the experiments were dodecane, tridecane, tetradecane, and pentadecane.

Robust imaging approach for precise prediction of postoperative lung function in lung cancer patients prior to curative operation.

Background: To create a combined variable integrating both ventilation and perfusion as measured by preoperative dual-energy computed tomography (DECT), compare the results with predicted postoperative (PPO) lung function as estimated using conventional methods, and assess agreement with actual postoperative lung function.

Methods: A total of 33 patients with lung cancer who underwent curative surgery after DECT and perfusion scan were selected. Ventilation and perfusion values were generated from DECT data.

Comparative Analysis of Atezolizumab Plus Bevacizumab and Hepatic Artery Infusion Chemotherapy in Unresectable Hepatocellular Carcinoma: A Multicenter, Propensity Score Study.

This study aimed to compare the prognosis and characteristics of patients with advanced hepatocellular carcinoma treated with first-line atezolizumab plus bevacizumab (AB) combination therapy and hepatic artery infusion chemotherapy (HAIC). We retrospectively assessed 193 and 114 patients treated with HAIC and AB combination therapy, respectively, between January 2018 and May 2023. The progression-free survival (PFS) of patients treated with AB combination therapy was significantly superior to that of patients treated with HAIC ( < 0.

Rh(III)-Catalyzed C8-Spiroannulation of 1-Aminonaphthalenes with Maleimides.

The rhodium(III)-catalyzed C8-spiroannulation of 1-aminonaphthalenes with maleimides is described herein. Initially formed C8-alkenylated 1-aminonaphthalenes can intercept nucleophilic 1-amino groups through the intramolecular aza-Michael reaction, resulting in the formation of spirofused tetracyclic frameworks. This protocol displayed a wide substrate scope and a broad functional group compatibility.

Sustainable Removal of BTEX Gas Using Regenerated Metal Containing SiO.

In the last decades, the removal of benzene, toluene, ethylbenzene, and xylene (BTEX) has been considered a major environmental crisis. In this study, two novel nanocomposite materials (Fe2O3/SiO2 and Fe2O3-Mn2O3/SiO2) that have regeneration ability by UV irradiation have been fabricated to remove BTEX at ambient temperature. This research revealed that both nanocomposites could remove more than 85% of the BTEX in the first cycle.

A Novel Metal-Containing Mesoporous Silica Composite for the Decolorization of Rhodamine B: Effect of Metal Content on Structure and Performance.

A series of novel MnFe@SiO (x,y = 1-20%) nanocomposites were synthesized for the first time via the sol-gel/combustion method with different content of precursors (Mn and Fe acetate salts). The effect of precursor content and ratio on physicochemical properties were observed by various characterization methods. Moreover, Rhodamine B (RhB) was chosen as the target pollutant to test the performance of these nanocomposites under a photocatalytic Fenton-like reaction.

Harnessing Waste Heat from Indoor lamps for Sustainable Thermocatalytic Mineralization of Acetaldehyde using Platinized TiO.

This study demonstrates the first reported thermocatalytic oxidation of an indoor volatile organic compound (VOC), acetaldehyde, by harnessing the waste-heat energy from indoor light sources (e.g., halogen lamps) without additional energy inputs.

Synthesis of Succinimide-Linked Indazol-3-ols Derived from Maleimides under Rh(III) Catalysis.

The structural modification of -aryl indazolols as tautomers of -aryl indazolones has been established as a hot topic in pharmaceutics and medicinal chemistry. We herein disclose the rhodium(III)-catalyzed 1,4-addition reaction of maleimides with -aryl indazol-3-ols, which provides the succinimide-bearing indazol-3-ol scaffolds with complete regioselectivity and a good functional group tolerance. Notably, the versatility of this protocol is demonstrated by the use of drug-molecule-linked and fluorescence-probe-linked maleimides.

Correction: Terephthalate and trimesate metal-organic frameworks of Mn, Co, and Ni: exploring photostability by spectroscopy.

[This corrects the article DOI: 10.1039/D1RA00181G.].

Terephthalate and trimesate metal-organic frameworks of Mn, Co, and Ni: exploring photostability by spectroscopy.

We report a rapid synthesis for the fabrication of terephthalate and trimesate metal-organic frameworks (MOFs) of Mn, Co, and Ni by ultrasonication of organic linkers with freshly prepared metal hydroxides. The MOFs were characterized by various microscopic and spectroscopic techniques to understand their structural, functional, and optical properties. MOFs with low bandgap energy (1.

Particulate Matter Promotes Melanin Production through Endoplasmic Reticulum Stress‒Mediated IRE1α Signaling.

Particulate matter (PM) is believed to be related to cardiovascular and respiratory diseases. The skin is also known to be affected by PM exposure as a result of skin barrier dysfunction, cutaneous inflammation, and apoptotic cell death. Epidemiological studies have suggested that PM is related to pigment spots.

Site-selective and metal-free C-H nitration of biologically relevant N-heterocycles.

The site-selective and metal-free C-H nitration reaction of quinoxalinones and pyrazinones as biologically important N-heterocycles with t-butyl nitrite is described. A wide range of quinoxalinones were efficiently applied in this transformation, providing C7-nitrated quinoxalinones without undergoing C3-nitration. From the view of mechanistic point, the radical addition reaction exclusively occurred at the electron-rich aromatic region beyond electron-deficient N-heterocycle ring.

Synthesis of spirosuccinimides annulative cyclization between -aryl indazolols and maleimides under rhodium(III) catalysis.

The rhodium(III)-catalyzed spiroannulation reaction between -aryl indazol-3-ols and maleimides is described herein. The developed method is showcased by the construction of spirosuccinimides using bioactive molecule-linked and chemical probe-linked maleimides. Combined mechanistic investigations including the determination of an isolable rhodacycle complex aided the elucidation of a plausible reaction mechanism.

Molecule-Resolved Visualization of Particulate Matter on Human Skin Using Multimodal Nonlinear Optical Imaging.

Precise measurement of particulate matter (PM) on skin is important for managing and preventing PM-related skin diseases. This study aims to directly visualize the deposition and penetration of PM into human skin using a multimodal nonlinear optical (MNLO) imaging system. We successfully obtained PM particle signals by merging two different sources, C-C vibrational frequency and autofluorescence, while simultaneously visualizing the anatomical features of the skin via keratin, collagen, and elastin.

Site-Selective C8-Alkylation of Quinoline -Oxides with Maleimides under Rh(III) Catalysis.

The site-selective modification of quinolines and their analogs has emerged as a pivotal topic in medicinal chemistry and drug discovery. Herein, we describe the rhodium(III)-catalyzed C8-alkylation of quinoline -oxides with maleimides as alkylating agents, resulting in the formation of bioactive succinimide-containing quinoline derivatives. The reaction proceeds under mild conditions with complete functional group tolerance.

Fabrication of Zn-MOF/ZnO nanocomposites for room temperature HS removal: Adsorption, regeneration, and mechanism.

Zn-MOF/ZnO nanocomposites with different organic linkers were fabricated by a rapid ultrasonication method using freshly prepared Zn(OH) precipitate. The high metal-to-ligand ratio led to the simultaneous formation of MOFs and ZnO nanoparticles in the MOFs. The surface area was in the range of 12-21 m g.

Chemisorption of hydrogen sulfide over copper-based metal-organic frameworks: methanol and UV-assisted regeneration.

Three copper-based metal-organic frameworks (MOFs) with different organic linkers were synthesized for the removal of HS gas at room temperature. The synthesized MOFs were characterized by microscopic and spectroscopic techniques to understand their structural, functional, and optical properties. The HS adsorption capacity of MOFs calculated by column studies followed the trend: 105.

Length difference of multi-walled carbon nanotubes generates differential cytotoxic responses.

Carbon nanotubes have recently been rated as an effective biomaterial owing to their functionalization ability. However, the safety of multi-walled carbon nanotubes (MWCNTs) has yet to be clearly understood. To investigate how cells differentially react to minor geometric differences, we prepared well-dispersed and stable long and short MWCNTs showing an approximately 100-nm length difference in an in vitro system.

UV-activated adsorbents as novel materials for enhanced removal of malodorous gases.

The performance of UV-activated FeO-containing ZSM-5 (UFZ5) and silica (UFS) as adsorbents for the removal of low concentration of volatile organic sulfur compounds (VOSCs) was investigated in ambient conditions. A ∼99.9% and ∼89.