Publications by authors named "Suhanya Okeke"
Prcis: The initial presentation of glaucoma varies meaningfully across SSA. A comprehensive strategy with regional customization based on local differences is needed to reduce glaucoma blindness in SSA.
Purpose: To explore regional variations in the presentation of newly diagnosed glaucoma in Sub Saharan Africa (SSA).
Article Synopsis
- Primary open-angle glaucoma is more common and severe in people of African descent compared to those of European or Asian ancestry, yet they are often overlooked in genetic research on this condition.
- The study conducts a genome-wide association study (GWAS) involving nearly 10,000 participants from various countries to identify genetic links to the disease.
- Results suggest significant genetic variants associated with primary open-angle glaucoma, highlighting the need for more focused research on affected populations for better understanding and treatment options.
Aim: The aim of this study was to determine the level of awareness and knowledge of glaucoma and the proportion of people with glaucoma among participants of a 1-day urban eye outreach programme.
Methods: The study was a cross-sectional survey. Data, collected by means of a structured questionnaire, included participants' demographic details, and awareness, knowledge and ocular status as regards glaucoma.
Article Synopsis
- Exfoliation syndrome (XFS) is a significant risk factor for secondary glaucoma, contributing to blindness globally, with known genetic variants in LOXL1 and CACNA1A linked to the condition.
- Researchers conducted a study analyzing samples from multiple countries, discovering a rare protective allele at LOXL1 and refining its association, which had been previously inconsistent across different populations.
- A genome-wide association study identified seven significant genetic loci related to XFS, providing new insights into its biological mechanisms and emphasizing the role of rare LOXL1 variants in the disease's development.