Medication stewardship in the operating theatre in Malaysia: A quality improvement project.

Background And Aims: A quality improvement project ('Safe Anaesthesia for ALL-SEAL') was implemented to reduce preventable medication errors and drug wastage in the operating theatre (OT) of a tertiary hospital. The primary objective of this quality improvement project was to prevent the incidence of medication errors, and the secondary objective was to reduce the wastage of unused drugs.

Methods: A pre-intervention questionnaire and an audit survey were performed, and multidirectional interventions were designed post-survey.

Characterization of four novel actinospore types of fish parasitic myxozoans and the occurrence of and from fish farms of Hungary.

Six distinct actinospore types were identified in the intestinal epithelium of oligochaetes collected from the Szigetbecse and Makád fish farms of Ráckeve Danube Arm Fishing Association, in Hungary. Four new types: triactinomyxon type, raabeia type, aurantiactinomyxon type 1, and aurantiactinomyxon type 2, were described morphologically and molecularly from three invertebrate host species: , and . The 18S ribosomal DNA (rDNA) analysis revealed that these new types of actinospores did not match any myxospore sequences available in GenBank.

Immunogenicity of monoclonal antibody: Causes, consequences, and control strategies.

Antibody-based treatment was first used in 1891 for the treatment of diphtheria. Since then, monoclonal antibodies (mAbs) have been developed to treat many diseases such as cancer and act as vaccines. However, murine-derived therapeutic mAbs were found to be highly immunogenic, and caused anti-drug antibodies (ADAs) reaction, reducing their efficacy and causing severe infusion reactions.

Predictions of PM using air pollutants and meteorological factors with COVID-19 cases in Malaysia and Indonesia: a comparative study using feature selection and robust regression.

The study examines the relationship between air quality, meteorological factors, and COVID-19 cases in Cheras, Kuala Lumpur, and Kelapa Gading, North Jakarta. Analyzing data from 2020 and 2021, the research found notable correlations: COVID-19 cases in Cheras were positively associated with relative humidity (RH) and carbon monoxide (CO) but negatively with ozone (O₃) and RH in different years. In Kelapa Gading, COVID-19 cases were positively correlated with pollutants like sulfur dioxide (SO₂) and CO, while ambient temperature (AT) showed a negative correlation.

First record and description of actinospore stages (raabeia, triactinomyxon, and aurantiactinomyxon types) of fish parasitic myxozoans from Malaysia.

During a 2-month survey in 2023 at Tasik Telabak, Terengganu, Malaysia three distinct actinospore types, namely raabeia, triactinomyxon and aurantiactinomyxon were identified in three invertebrate host species: , sp., and sp. utilizing morphometric and molecular analyses Maximum likelihood of 18S rDNA positioned the raabeia type within the clade from fish of the Order Cypriniformes, suggesting a detected actinospore has a potential life cycle development in Cypriniformes and the genus .

The association between indoor air quality and respiratory health symptoms among preschool children in Penang, Malaysia.

A cross-sectional study was conducted among 126 preschool children aged 4-6 years in traffic, industrial, and suburban areas of Penang, Malaysia, to determine their exposure to indoor air pollutants and their associations with respiratory symptoms. A standardised and validated questionnaire was used to collect data on respiratory health symptoms among respondents. An indoor air quality assessment was conducted in selected preschools that included temperature, relative humidity, air velocity, volatile organic compounds (VOCs), and particulate matter (PM, and PM).

Expansion of omega-3 polyunsaturated fatty acid metabolism of the oleaginous diatom Fistulifera solaris by genetic engineering.

Omega-3 polyunsaturated fatty acids (PUFAs), such as eicosapentaenoic acid (EPA; C20:5n-3) and docosahexaenoic acid (DHA; C22:6n-3) are widely used as additives in fish feed in the aquaculture sector. To date, the supply of omega-3 PUFAs have heavily depended upon fish oil production. As the need for omega-3 PUFAs supply for the growing population increases, a more sustainable approach is required to keep up with the demand.

An 8-Week Vitamin D3-Fortified Fruit Drink Supplementation Increases Serum Ferritin Concentration: A Randomized Controlled Trial in Malaysian Women With Low Iron Stores.

Background: There is limited randomized controlled trial evidence to support the association between vitamin D deficiency and anemia risk, highlighting the necessity for further investigations into the role of vitamin D in influencing iron status.

Objective: The aim of this study was to determine the effect of vitamin D3-fortified fruit drink consumption (4,000 IU) on vitamin D and iron status biomarkers among iron-deficient women (serum ferritin of <20 μg/L [to convert μg/L ferritin to ng/mL, multiply by 1]).

Design: An 8-week double-blind randomized controlled trial was conducted.

Morphological and molecular characterisation of two closely related species: n. sp. and Reuss, 1906.

Based on spore morphology and small subunit ribosomal DNA sequences, we describe a new species, n. sp., parasitizing the European perch () from Lake Balaton in Hungary.

From defense to offense: Modulating toll-like receptors to combat arbovirus infections.

Arboviruses are a significant threat to global public health, with outbreaks occurring worldwide. Toll-like receptors (TLRs) play a crucial role in the innate immune response against these viruses by recognizing pathogen-associated molecular patterns and initiating an inflammatory response. Significantly, TLRs commonly implicated in the immune response against viral infections include TLR2, TLR4, TLR6, TLR3, TLR7, and TLR8; limiting or allowing them to replicate and spread within the host.

Chromosome-scale genome assembly of an acidophilic microalga sp. P1 isolated from a tropical peatland in Malaysia.

sp. P1 shows an acidophilic phenotype which could allow mass-scale monoculture of this green microalga without severe contamination by environmental microorganisms. In this study, we report a chromosome-scale genome assembly for sp.

The clinical implications of Porphyromonas gingivalis and its detection methods - a systematic review.

Introduction: Mounting evidence has shown the significant correlation between periodontitis and the development of other comorbidities, such as cardiovascular disease due to periodontopathogenic bacterial migration and colonisation. As the main etiologic agent of periodontitis, the role of Porphyromonas gingivalis (P. gingivalis) has been widely explored as the main culprit and its early detection is crucial to control the exacerbation of diseases.

Evaluating the underlying physiological and molecular mechanisms in the system of rice intensification performance with -rice plant symbiosis as a model system.

The system of rice intensification (SRI) is an extensively-researched and increasingly widely-utilized methodology for alleviating current constraints on rice production. Many studies have shown physiological and morphological improvements in rice plants induced by SRI management practices to be very similar to those that are associated with the presence of beneficial microbial endophytes in or around rice plants, especially their roots. With SRI methods, grain yields are increased by 25-100% compared to conventional methods, and the resulting plant phenotypes are better able to cope with biotic and abiotic stresses.

The first detection of Myxobolus lentisuturalis Dyková, Fiala et Nie, 2002, a highly pathogenic muscle-infecting parasite of gibel carp (Carassius auratus gibelio Berg, 1932) in Hungary.

Myxobolus lentisuturalis is a myxosporean parasite infecting the musculature both of goldfish (Carassius auratus auratus) and gibel carp (Carassius auratus gibelio). The species was originally described in China from gibel carp that is a common fish for sport fishing in Hungary meanwhile is one of the most popular farmed fish in China due to its high demand. Eighteen gibel carp with distortions were collected from a barrage pond in southern Hungary.

Microstructure and Superconducting Properties of Bi-2223 Synthesized via Co-Precipitation Method: Effects of Graphene Nanoparticle Addition.

The effects of graphene addition on the phase formation and superconducting properties of (BiPb)SrCaCuO (Bi-2223) ceramics synthesized using the co-precipitation method were systematically investigated. Series samples of Bi-2223 were added with different weight percentages ( = 0.0, 0.

Traffic-Related Air Pollution (TRAP) in relation to respiratory symptoms and lung function of school-aged children in Kuala Lumpur.

Traffic-Related Air Pollution (TRAP) exposure has been connected to significant health impacts among children. A cross-sectional comparative study was conducted among school children in Malaysia to determine the relationship between their exposure to TRAP and respiratory health effects. Air monitoring was conducted in schools and residences, while the children's routines were investigated using a diary of daily activities.

Crude extracts of an endophytic fungus attenuate the growth of pathogenic bacteria in aquaculture.

Background And Objectives: Endophytic fungi are believed to possess compounds as antibacterial agents. This study was designed to determine antibacterial activity of the crude extracts from IBRL OS-64 against pathogenic bacteria.

Materials And Methods: The qualitative and quantitative screenings were performed using agar plug and disk diffusion antimicrobial tests, respectively.

Combating chlorhexidine allergy in perioperative setting.

Chlorhexidine is labelled as hidden allergen as the health care professionals (HCPs) are unaware of the wide range of products containing chlorhexidine. Adverse events from chlorhexidine allergy can be reduced by appropriate perioperative management especially heeding on positive history during preoperative assessment, awareness regarding this hidden allergen, and educating HCPs on possible chlorhexidine-containing products. The regulatory agencies all over the world have issued recommendations regarding safety and risk of hypersensitivity reactions with chlorhexidine-containing products.

Synthesis of ZIF-8 tubular membrane via solvent evaporation seeding coupled with microwave assisted heating method for separation of small molecule gases.

In this work, we systematically study the performance of tubular ZIF-8 membranes in the separation of small molecules including H, CO, N and CH The tubular ZIF-8 membranes were synthesized on α-alumina support via novel dual approach known as solvent evaporation seeding coupled with microwave assisted growth. The durations for the growth of the seed layer through solvent evaporation and membrane layer via microwave heating were varied. The crystallinity and morphology of the resultant membranes were evaluated by using XRD, SEM and IFM analyses.

Vaccine for Diabetes-Where Do We Stand?

Diabetes is an endocrinological disorder with a rapidly increasing number of patients globally. Over the last few years, the alarming status of diabetes has become a pivotal factor pertaining to morbidity and mortality among the youth as well as middle-aged people. Current developments in our understanding related to autoimmune responses leading to diabetes have developed a cause for concern in the prospective usage of immunomodulatory agents to prevent diabetes.

Enrichment of biogas through composite membrane of PEBA-1657/ hierarchical T-type zeolite.

Presently, composite membranes emerged as a promising approach to overcome the limitations of polymeric and inorganic membranes particularly in acid gas separation. In the present work, composites membranes were fabricated by combining hierarchical T-Type (h-zeolite T) zeolite and PEBA-1657 at different filler composition that ranging from 5 wt% - 30 wt% for the CO/CH separation. The physicochemical properties of the resultant inorganic filler and membranes were investigated by using Brunauer-Emmett- Teller (BET), field emission scanning electron microscopy (FESEM), Fourier Transform infra-red (FTIR), x-ray diffraction (XRD), thermogravimetric analysis (TGA) and differential scanning calorimetry (DSC).

Nanoparticles for the treatment of glaucoma-associated neuroinflammation.

Recently, a considerable amount of literature has emerged around the theme of neuroinflammation linked to neurodegeneration. Glaucoma is a neurodegenerative disease characterized by visual impairment. Understanding the complex neuroinflammatory processes underlying retinal ganglion cell loss has the potential to improve conventional therapeutic approaches in glaucoma.

Application of liposomes in the treatment of infectious diseases.

The advances in the development of drugs and vaccines for major infectious diseases of tuberculosis (TB), malaria and HIV represent some of the most significant milestones in their therapeutic strategies. Yet, current drugs and vaccines display limitations such as drug resistance and low efficacy level. In recent years, new emerging and advanced nano-technology carrier liposomes have been widely studied towards producing drugs and vaccines capable of targeting infectious diseases.

Development of Amine-Functionalized Metal-Organic Frameworks Hollow Fiber Mixed Matrix Membranes for CO and CH Separation: A Review.

CO separation from raw natural gas can be achieved through the use of the promising membrane-based technology. Polymeric membranes are a known method for separating CO but suffer from trade-offs between its permeability and selectivity. Therefore, through the use of mixed matrix membranes (MMMs) which utilizes inorganic or hybrid fillers such as metal-organic frameworks (MOFs) in polymeric matrix, the permeability and selectivity trade-off can be overcome and possibly surpass the Robeson Upper Bounds.