In Silico Guided Nanoformulation Strategy for Circumvention of Biofilm for Effective Therapy of Candidal Vulvovaginitis.

Candidal vulvovaginitis involving multispecies of and epithelium-bound biofilm poses a drug-resistant pharmacotherapeutic challenge. The present study aims for a disease-specific predominant causative organism resolution for the development of a tailored vaginal drug delivery system. The proposed work fabricates a luliconazole-loaded nanostructured lipid carrier-based transvaginal gel for combating biofilm and disease amelioration.