I-DMSO Promoted Deaminative Coupling Reactions of Glycine Esters: Access to 5-(Methylthio)pyridazin-3(2)-ones.

An unprecedented, one-step strategy for the synthesis of 5-(methylthio)pyridazin-3(2)-one derivatives has been developed through iodine triggered deaminative coupling of glycine esters with methyl ketones and hydrazine hydrate in DMSO. These transformations in the absence of hydrazine helped to generate different 3-methylthio-4-oxo-enoates in good yields. Notably, DMSO played multiple roles such as oxidant, methylthiolating reagent, and solvent.

Iodine and ammonium persulfate mediated activation of DMSO: an approach to -formylation of amides and synthesis of isatins.

An efficient strategy towards -formylation of amides and oxidation of indolines to isatins is described. This method employs readily available (NH)SO, I, and DMSO. The given method features operational simplicity, excellent functional group tolerance, broad substrate scope, and fast kinetics.

Cesium-Fluoride-Promoted Synthesis of Stable Organocesium Reagents and Their Ambident Reactivities with Arynes.

Described are the diverse reactivities of novel, stable, ambident thio-organocesium reagents (bearing electron withdrawing groups) against benzynes. Reactions at reflux temperature predominantly led to the generation of various functionalized stable sulfonium ylides and at 40 °C the same reaction underwent direct c-arylation. Furthermore, lack of internal hydrogen on the cesium reagent helped to produce different ortho-bifunctional arynes in both the reactions.

Thirty-six Entangled Officers of Euler: Quantum Solution to a Classically Impossible Problem.

The negative solution to the famous problem of 36 officers of Euler implies that there are no two orthogonal Latin squares of order six. We show that the problem has a solution, provided the officers are entangled, and construct orthogonal quantum Latin squares of this size. As a consequence, we find an example of the long-elusive Absolutely Maximally Entangled state AME(4,6) of four subsystems with six levels each, equivalently a 2-unitary matrix of size 36, which maximizes the entangling power among all bipartite unitary gates of this dimension, or a perfect tensor with four indices, each running from one to six.

Sulfonyl-Promoted Michaelis-Arbuzov-Type Reaction: An Approach to S/Se-P Bonds.

By facilitating the chemical conversion of thiols to thiosulfonates, phosphoramidite/phosphite bearing sp-hybridized carbon serves as an ideal coupling material to forge new connections at room temperature. In this work, a functional group-induced, additive-free, novel, S-P bond-forming approach is presented. This protocol exhibits good functional group tolerance with wide applications that include phosphorylation of cysteine derivatives, development of a one-pot approach to mixed unsymmetrical thiophosphonates, and extension of the concept to different Se-P bonds.

Creating Ensembles of Dual Unitary and Maximally Entangling Quantum Evolutions.

Maximally entangled bipartite unitary operators or gates find various applications from quantum information to many-body physics wherein they are building blocks of minimal models of quantum chaos. In the latter case, they are referred to as "dual unitaries." Dual unitary operators that can create the maximum average entanglement when acting on product states have to satisfy additional constraints.

Iodine-DMSO-promoted divergent reactivities of arylacetylenes.

An unprecedented set of efficient, economical, atom-economic and exceedingly selective I2-DMSO-promoted methods is described for the generation of different structures. The reaction represents the first of its kind, involving the use of different iodine concentrations, temperatures, acids and salt to adjust the selectivity for the synthesis of different alkenes, α-functionalized ketones and α-ketomethylthioesters.

Introducing Oxo-Phenylacetyl (OPAc) as a Protecting Group for Carbohydrates.

A series of oxo-phenylacetyl (OPAc)-protected saccharides, with divergent base sensitivity profiles against benzoyl (Bz) and acetyl (Ac) were synthesized, and KHSO/AcCl in methanol was identified as an easy, mild, selective, and efficient deprotecting reagent for their removal in the perspective of carbohydrate synthesis. Timely monitoring of AcCl reagent was supportive in both sequential and simultaneous deprotecting of OPAc, Bz, and Ac. The salient feature of our method is the orthogonal stability against different groups, its ease to generate different valuable acceptors using designed monosaccharides, and use of OPAc as a glycosyl donar.