Publications by authors named "Suguru Kitahara"
Arch Biochem Biophys
September 2012
Article Synopsis
- Dipeptidyl peptidase III (DPP III) contains a unique helix in its metal-binding region, which is crucial for enzyme activity.
- Cu(II)-rat DPP III demonstrates reduced activity compared to its wild-type form, while a modified version with a deletion (del-DPP III) drastically loses its enzyme function.
- The deletion of Leu453 disrupts the enzyme's flexibility around copper ions, affecting the formation of the enzyme-metal-substrate complex and altering the accessibility of a key residue (Glu451) to water.
