Publications by authors named "Suguru Iwata"
Article Synopsis
- The study investigates how the development of branches of the subclavian artery is influenced by the anatomy of the proximal artery and surrounding structures, particularly in response to blood flow stress.
- A case of an aberrant right subclavian artery arising from the aorta and unusual branching patterns was reported, revealing types H and CG of the Adachi-Williams classification.
- Findings indicate that while the aberrant artery's development can impact blood flow in the region, normal distal branching suggests that proximal and distal vascular development can operate independently, adapting to anomalies.
Epilepsy is a common neurological disease worldwide, and one of its causes is genetic abnormalities. Here, we identified a point mutation in KIF4A, a member of kinesin superfamily molecular motors, in patients with neurological disorders such as epilepsy, developmental delay, and intellectual disability. KIF4 is involved in the poly (ADP-ribose) polymerase (PARP) signaling pathway, and the mutation (R728Q) strengthened its affinity with PARP1 through elongation of the KIF4 coiled-coil domain.
View Article and Find Full Text PDFSynaptic weight changes among postsynaptic densities within a single dendrite are regulated by the balance between localized protein degradation and synthesis. However, the molecular mechanism via these opposing regulatory processes is still elusive. Here, we showed that the molecular motor KIF17 was locally degraded and synthesized in an -methyl-d-aspartate receptor (NMDAR)-mediated activity-dependent manner.
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