Publications by authors named "Suguna Mallesh"
Two structurally unrelated small molecule chemotypes, represented by compounds PAV-617 and PAV-951, with antiviral activity in cell culture against Mpox virus (formerly known as monkeypox virus) and human immunodeficiency virus (HIV) respectively, were studied for anti-cancer efficacy. Each exhibited apparent pan-cancer cytotoxicity with reasonable pharmacokinetics. Non-toxicity is demonstrated in a non-cancer cell line and in mice at doses achieving drug exposure at active concentrations.
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- Researchers developed a new small molecule antiviral called PAV-431 that was discovered through a unique screening method targeting viral protein assembly.
- This compound has shown effectiveness against various respiratory viruses in laboratory studies and in animal models, including coronaviruses and paramyxoviruses.
- PAV-431 works by selectively targeting a modified protein complex involved in the viral life cycle, providing a potential new approach for treating respiratory viral infections without harming the host.
We present a novel small molecule antiviral chemotype that was identified by an unconventional cell-free protein synthesis and assembly-based phenotypic screen for modulation of viral capsid assembly. Activity of PAV-431, a representative compound from the series, has been validated against infectious virus in multiple cell culture models for all six families of viruses causing most respiratory disease in humans. In animals this chemotype has been demonstrated efficacious for Porcine Epidemic Diarrhea Virus (a coronavirus) and Respiratory Syncytial Virus (a paramyxovirus).
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