"Substituent on benzenesulfonyl group" effect in use of 8-benzenesulfonamidoquinoline derivatives as chelate extractant.

"Substituent on benzenesulfonyl group" effect of 8-benzenesulfonamidoquinoline [N-(8-quinolyl)benzenesulfonamide, Hbsq] as bidentate chelate extractant for divalent metal cations was investigated with using Hbsq and its eight derivatives. Introduction of electron-withdrawing substituent on the benzenesulfonyl group in Hbsq enhanced the extractability that originated from its inductive effect. Furthermore, a bulky substituent on an ortho-position of the benzenesulfonyl group resulted in no steric effect in extraction, whereas the existence of two substituents on each ortho-position caused lower extraction performance due to steric hindrance.

Solution- and solid-state structures of N-desmethylnefopam hydrochloride, a metabolite of the analgesic drug.

The solid-state structure of (+/-)-N-desmethylnefopam hydrochloride (1), a metabolite of the analgesic drug, was determined by single-crystal X-ray diffraction analysis. Compound 1 gave crystalline prisms belonging to the orthorhombic Pcab space group, and at ambient temperature (293 K), a = 9.939(2), b = 14.

Rapid molecular size characterization of heparins by high pressure liquid chromatography.

Extremely fast molecular size separations of heparins have been demonstrated using modern high pressure liquid chromatography technology. Commercial USP grade heparins of beef and porcine origin were characterized within 7 minutes. Their molecular size distribution characteristics and molecular weight relative to nonionic dextrans were obtained and found to exhibit a higher molecular weight for porcine and a lower molecular weight for beef heparin.