Seasonal variations and a demographic analysis of digital evacuation incidence for constipation management: A Japanese population-based cohort study.

Objective Digital evacuation (DE) is an intervention used to address severe constipation. Literature exists on easily administered laxatives; however, reports on mildly invasive DE usage are limited. This study aimed to elucidate the fundamental data regarding constipation management using a comprehensive national database of DE incidence.

Development of high-quality artificial intelligence for computer-aided diagnosis in determining subtypes of colorectal cancer.

Background And Aim: There are no previous studies in which computer-aided diagnosis (CAD) diagnosed colorectal cancer (CRC) subtypes correctly. In this study, we developed an original CAD for the diagnosis of CRC subtypes.

Methods: Pretraining for the CAD based on ResNet was performed using ImageNet and five open histopathological pretraining image datasets (HiPreD) containing 3 million images.

The Comparison of Diagnostic Ability between Blue Laser/Light Imaging and Narrowband Imaging for Sessile Serrated Lesions with or without Dysplasia.

Objectives: Diagnostic ability of sessile serrated lesions (SSL) and SSL with dysplasia (SSLD) using blue laser/light imaging (BLI) has not been well examined. We analyzed the diagnostic accuracy of BLI for SSL and SSLD using several endoscopic findings compared to those of narrow band imaging (NBI).

Materials And Methods: This was a subgroup analysis of prospective studies.

Efficacy of Glycicumarin and Isoliquiritigenin in Suppressing Colonic Peristalsis in Both an Animal Model and a Clinical Trial.

Patients with diarrhea-predominant irritable bowel syndrome (IBS-D) show excessive peristalsis, and antispasmodic agents may be useful therapeutic agents. There are few reports on the use of Kampo medicines for the treatment of IBS-D. Shakuyakukanzoto (SKT) is a Kampo medicine that is effective against abdominal pain.

Canonical BAF complex regulates the oncogenic program in human T-cell acute lymphoblastic leukemia.

Acute leukemia cells require bone marrow microenvironments, known as niches, which provide leukemic cells with niche factors that are essential for leukemic cell survival and/or proliferation. However, it remains unclear how the dynamics of the leukemic cell-niche interaction are regulated. Using a genome-wide CRISPR screen, we discovered that canonical BRG1/BRM-associated factor (cBAF), a variant of the switch/sucrose nonfermenting chromatin remodeling complex, regulates the migratory response of human T-cell acute lymphoblastic leukemia (T-ALL) cells to a niche factor CXCL12.

Follow the time course of inflammation caused by intraperitoneal administration of multi-wall carbon nanotubes in mice.

Objective: Understand the progress of inflammation over time caused by multi-walled carbon nanotubes (MWCNT).

Methods: Two types of MWCNTs were administered to C57BL/6N mice via intraperitoneal administration at low and high doses (0.05 and 1.

Contaminant microorganisms in the evaluation of cellular responses of cellulose nanofibers and their microbial inactivation using gamma irradiation.

Cellulose nanofibers (CNFs) are fibrous nanomaterials produced from plants. Since some nanomaterials are toxic, toxicity evaluation, including examinations using cultured cells, is essential for the effective use of CNFs. On the other hand, microorganisms in the environment can contaminate CNF suspensions.

A case of hyponatremia attributed to carboplatin-induced syndrome of inappropriate anti-diuretic hormone.

•A patient who used carboplatin in the treatment of ovarian cancer developed SIADH.•She was able to continue treatment with regular salt intake.•This treatment may be an option for similar patients in the future.

A case of sudden multiple hematomas during cesarean section due to amniotic fluid embolism.

Introduction: We report a case of multiple hematomas, a rare manifestation of amniotic fluid embolism (AFE), during cesarean section.

Presentation Of Case: The patient had a history of pregnancy and cesarean section birth due to placental abruption. At 38 weeks and 2 days, her membrane ruptured, and an emergency cesarean section was performed.

Partially hydrolyzed guar gum increased colonic mucus layer in mice via succinate-mediated MUC2 production.

Colonic mucus layers protect intestinal tissues against intestinal bacteria. We investigated the effects of dietary fiber and its metabolites on mucus production in the colonic mucosa. Mice were fed a partially hydrolyzed guar gum (PHGG)-containing diet and a fiber-free diet (FFD).

Standard Endoscopic Mucosal Resection vs Precutting Endoscopic Mucosal Resection Using Novel Disk-Tip Snare for Colorectal Lesions.

Introduction: SOUTEN (KANEKA Co., Tokyo, Japan) is a unique snare with a disk tip. We analyzed the efficacy of precutting endoscopic mucosal resection with SOUTEN (PEMR-S) for colorectal lesions.

Zinc Deficiency-Associated Dysgeusia Preventing the Improvement of Severe Hyperemesis Gravidarum.

A 23-year-old primigravida visited the hospital frequently since the early phase of her pregnancy because of severe hyperemesis gravidarum. She was hospitalized for the same at 14 weeks and 1 day of pregnancy. After admission, peripheral intravenous nutrition was started; however, her symptoms did not improve.

Outcomes of pediatric obesity-related lifestyle disease screenings in Kumamoto.

Background: Obesity is an important issue causing both health hazards and socioeconomic loss to those affected. Kumamoto City regularly performs obesity-related lifestyle disease screenings for fourth grade children with obesity, including physical examinations, blood tests, and special examination referrals. We retrospectively analyzed the outcomes of the screenings conducted from 2011 to 2020.

A Case of Postpartum Pulmonary Edema With Preserved Ejection Fraction and Diastolic Capacity.

A 21-year-old female patient delivered vaginally at 40 weeks of gestation after an uneventful pregnancy. She bled profusely during delivery and underwent a blood transfusion and was discharged home on postpartum day 6. On postpartum day 8, she developed respiratory distress and visited our emergency room.

A case of endometriotic cyst enlargement during pregnancy owing to desmoplasia and rupture at 36 weeks of gestation.

Decidualized ovarian endometrioma is a rare phenomenon that occurs during pregnancy. A 43-year-old pregnant woman with an endometriotic cyst increased owing to desmoplasia presented to us urgently with abdominal pain and was performed a cesarean section at 36 weeks and 1 day of pregnancy. The left ovarian cyst was noted to be partially ruptured, and the pathological diagnosis was an endometriotic cyst with desmoplasia.