Publications by authors named "Sugata Ghosh"
Unlabelled: Of the more than 100 types of brain cancer, glioblastoma (GBM) is the deadliest. As GBM stem cells (GSCs) are considered to be responsible for therapeutic resistance and tumor recurrence, effective targeting and elimination of GSCs could hold promise for preventing GBM recurrence and achieving potential cures. We show here that , which encodes a histone-3, lysine-9 methyltransferase, plays a critical role in GSC maintenance and GBM progression.
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- - Glioblastoma (GBM) is the most aggressive brain cancer, largely driven by glioblastoma stem cells (GSCs) which contribute to its recurrence and make treatment difficult.
- - Natural killer (NK) cells have potential against GSCs but struggle with effectiveness in the GBM environment due to limited infiltration.
- - This study presents new image-based assays to evaluate NK cell movement and ability to kill GSCs, aiming to enhance NK cell immunotherapy for better GBM management.