Publications by authors named "Sufiyan Sufiyan"
Article Synopsis
- The research focuses on autophagy-associated genes and MicroRNAs (miRs) in glioma prognosis within the Pakistani population, exploring their roles in glioma development and patient survival.
- Utilizing techniques like real-time PCR and immunohistochemistry, the study analyzed expression levels of genes and miRs in glioma tissues, resulting in comprehensive statistical evaluations tailored to low- and high-grade gliomas.
- Findings showed significant gender and age demographics, with glioblastoma and astrocytoma being common subtypes, while revealing correlations between key prognostic markers and clinicopathological factors, alongside unique molecular signatures related to autophagy in different glioma grades.
High-grade gliomas are extremely fatal tumors, marked by severe hypoxia and therapeutic resistance. Autophagy is a cellular degradative process that can be activated by hypoxia, ultimately resulting in tumor advancement and chemo-resistance. Our study aimed to examine the link between autophagy markers' expression in low-grade gliomas (LGGs) and high-grade gliomas (HGGs).
View Article and Find Full Text PDFBackground: Lung adenocarcinoma (LUAD) is one of the most common types in the world with a high mortality rate. Despite advances in treatment strategies, the overall survival (OS) remains short. Our study aims to establish a reliable prognostic signature closely related to the survival of LUAD patients that can better predict prognosis and possibly help with individual monitoring of LUAD patients.
View Article and Find Full Text PDFIntroduction: Targeted therapies are based on specific gene alterations. Various specimen types have been used to determine gene alterations, however, no systemic comparisons have yet been made. Herein, we assessed alterations in selected cancer-associated genes across varying sample sites in lung cancer patients.
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