Safety and efficacy of peroral endoscopic myotomy for treating achalasia in pediatric and geriatric patients: A meta-analysis.

Background: As a less invasive technique, peroral endoscopic myotomy (POEM) has recently been widely accepted for treating achalasia with an excellent safety profile, durability, and efficacy in adults. In pediatric and geriatric patients, the treatment is more difficult.

Aim: To discuss the clinical outcomes of POEM in pediatric and geriatric patients with achalasia.

Cross-cultural adaptation and clinical application of the Perth Empathy Scale.

Objective: Alterations of empathy have been observed in patients with various mental disorders. The Perth Empathy Scale (PES) was recently developed to measure a multidimensional construct of empathy across positive and negative emotions. However, its psychometric properties and clinical applications have not been examined in the Chinese context.

Antidepressant Treatment-Induced State-Dependent Reconfiguration of Emotion Regulation Networks in Major Depressive Disorder.

Deficits in emotion regulation are the main clinical features, common risk factors, and treatment-related targets for major depressive disorder (MDD). The neural bases of emotion regulation are moving beyond specific functions and emphasizing instead the integrative functions of spatially distributed brain areas that work together as large-scale brain networks, but it is still unclear whether the dynamic interactions among these emotion networks would be the target of clinical intervention for MDD. Data were collected from 70 MDD patients and 43 sex- and age-matched healthy controls.

Effective Connectivity of Right Amygdala Subregions Predicts Symptom Improvement Following 12-Week Pharmacological Therapy in Major Depressive Disorder.

The low rates of treatment response still exist in the pharmacological therapy of major depressive disorder (MDD). Exploring an optimal neurological predictor of symptom improvement caused by pharmacotherapy is urgently needed for improving response to treatment. The amygdala is closely related to the pathological mechanism of MDD and is expected to be a predictor of the treatment.

Is quarantine related to immediate negative psychological consequences during the 2009 H1N1 epidemic?

Objective: To investigate whether being quarantined to contain H1N1 flu transmission is related to immediate negative psychological consequences or not.

Methods: Immediate psychological consequences were evaluated with the 20-item Self-Report Questionnaire (SRQ-20) and the Impact of Event Scale-Revised (IES-R) among 419 undergraduate students (176 being quarantined and 243 being nonquarantined).

Results: No significant difference was found between the quarantined group and the nonquarantined group for IES-R screening-positive rate or SRQ-20 screening-positive rate.