Publications by authors named "Sufan Ding"
Aim: Acute aortic dissection (AAD) represents a cardiovascular ailment characterised by a notable mortality rate. Chronobiological patterns can offer a predictive framework for anticipating the onset of AAD.
Method: Data were gathered from 1,151 patients diagnosed with AAD at Changhai Hospital in Shanghai, China, spanning 2000-2023.
Article Synopsis
- Pathological cardiac hypertrophy, which can lead to heart failure, involves complex mechanisms where deubiquitinating enzymes like OTUD1 play a vital role in regulating protein functions in heart cells.
- Researchers created specific mouse models (Otud1-CKO and adeno-associated virus serotype 9-Otud1) to study how Otud1 influences heart cell enlargement and identified critical interactions through various laboratory techniques, including RNA sequencing.
- Findings showed that elevated OTUD1 levels exacerbate cardiac hypertrophy by activating a specific signaling pathway (Ask1-p38/JNK) and that targeting the OTUD1-PGAM5 pathway could provide promising new treatments for heart failure related to cardiac hypertrophy.
Background: The accumulation of epicardial adipose tissue (EAT) is associated with cardiometabolic risks and adverse outcomes in heart failure with preserved ejection fraction (HFpEF) and atrial fibrillation (AF). This study aims to identify genes secreted by EAT that contribute to the shared pathogenesis of HFpEF and AF, potentially serving as biomarkers for diagnosis.
Methods: Data sets from the GEO database for HFpEF-EAT, HFpEF-heart tissue, AF-EAT, AF-PBMC, and AF-heart tissue were analyzed.