Obicetrapib as an Adjunct to Stable Statin Therapy in Japanese Subjects: Results from a Randomized Phase 2 Trial.

Aims: Obicetrapib is a highly selective cholesteryl ester transfer protein (CETP) inhibitor shown to reduce low-density lipoprotein cholesterol (LDL-C) and apolipoprotein B (apoB), when taken as monotherapy and in combination with ezetimibe on a background of statins, in clinical trials predominantly conducted in Northern European/Caucasian participants. We characterized the efficacy, safety, and tolerability of obicetrapib within an Asian-Pacific region population.

Methods: This double-blind, randomized, phase 2 trial examined obicetrapib 2.

Insect growth-regulating activity of 1-benzyl-2-methylbenzimidazole derivatives on silkworms.

Derivatives of 1-benzyl-2-methylbenzimidazoles (BMBIs) were synthesized to evaluate their biological activities against , a lepidopteran model insect. Synthesized BMBIs exhibited two different biological activities: inhibition of development and acute lethality. From a structural perspective, the activity varied with the position of the substitutions on the 1-benzyl moiety; BMBIs with substitutions on the 2 and/or 4 positions had comparatively high activity in comparison with those with substitutions on the 3-position.

Transition of blood glucose level in a patient with pregnancy-associated fulminant type 1 diabetes mellitus.

We report on the transition in blood glucose levels before and after the onset of fulminant type 1 diabetes mellitus in a perinatal woman. In week 38 of pregnancy, before which the patient had normal glucose tolerance, idiopathic acute pancreatitis was diagnosed. Five days thereafter, she became hypoglycemic, so we closely monitored her blood glucose levels.

PIEZO1 gene mutation in a Japanese family with hereditary high phosphatidylcholine hemolytic anemia and hemochromatosis-induced diabetes mellitus.

Hereditary xerocytosis (HX) or dehydrated hereditary stomatocytosis (DHS) [OMIM 194380], in which PIEZO1 gene mutation has recently been identified, is difficult to diagnose. We report here the discovery of a PIEZO1 gene mutation in a Japanese family (father, daughter, and son) who were previously diagnosed with hereditary high phosphatidylcholine hemolytic anemia (HPCHA). All of the affected family members had non-spherocytic hemolytic anemia associated with severe hemochromatosis-related diabetes mellitus.

Electroreductive intermolecular coupling of 3-methoxycarbonylindoles with ketones.

The electroreductive coupling of 1-alkoxycarbonyl-3-methoxycarbonylindoles with aromatic ketones in the presence of chlorotrimethylsilane gave cis-adducts stereoselectively. The cis-adducts were readily transformed to trans-adducts by treatment with catalyst DBU. On the other hand, the electroreductive coupling of 1-methyl-3-methoxycarbonylindole with aliphatic ketones in isopropanol afforded trans-adducts exclusively.

A Case of Acute Myocardial Infarction due to Left Main Trunk Occlusion Complicated With Aortic Dissection as Diagnosed by Intravascular Ultrasound.

A 52-year-old man was transferred to our hospital with a sudden onset of severe chest pains. His electrocardiogram revealed ST-segment elevation suggestive of acute myocardial infarction. Emergency coronary angiography showed subtotal occlusion of left main trunk (LMT) with delayed coronary flow.

Development of a tennis ball-sized tumor at the site of an implanted pacemaker.

A 77-year-old woman who had undergone a pacemaker implantation 6 years previously developed a tumor on the left side of the chest. The mass gradually grew to the size of a tennis ball and was excised along with the pacemaker generator. Histopathological examination revealed that the mass was a chronic expanding hematoma.

Soil microbial community structure in an Asian dust source region (Loess plateau).

The bacterial community structure in four geographically isolated arid regions on the Loess plateau, China, a source of Asian dust, was investigated using a 16S rRNA gene. Denaturing gradient gel electrophoresis and sequencing demonstrated that community diversity in the Loess plateau was low, and a common Alphaproteobacteria phylotype was identified. Phylogenetic analyses of arid soils revealed that most phylotypes had low similarity with known strains in various phyla, suggesting that these regions contain phylogenetically divergent and unknown bacteria.

Similarity of bacterial community structure between Asian dust and its sources determined by rRNA gene-targeted approaches.

The atmospheric movement of arid soil can play an important role in the movement of microorganisms attached to soil microparticles. Bacterial community structures in Asian dust collected at Beijing were investigated using the 16S rRNA gene sequence and compared to those in arid soil, a possible source of the dust. Asian dust samples contained 2.

Effect of conventional mechanical ventilation and jet ventilation on airway pressure in dogs and plastic models with tracheal stenosis.

Objective: To evaluate the effect of jet ventilation on tracheal stenosis in dogs and plastic models.

Design: Prospective, randomized trial in dogs, and multitrial tests in tracheal stenosis models.

Setting: Animal laboratory in a university setting.

DNA base and deoxyribose modification by the carbon-centered radical generated from 4-(hydroxymethyl)benzenediazonium salt, a carcinogen in mushroom.

Modification of the base and the sugar moieties of DNA with 4-(hydroxymethyl)benzenediazonium salt (HMBD), a carcinogen in the mushroom Agaricus bisporus, was investigated. When deoxyribonucleosides dGuo, dAdo, dThd, and dCyd were incubated with HMBD at pH 7.4 and 37 degrees C, the levels of all the nucleosides were decreased.

[Factors influencing delayed type graft-versus-host disease after allogeneic bone marrow transplantation].

Effects of the number of transplanted bone marrow cells and splenectomy performed before the transplantation on delayed type graft-versus-host disease (GVHD) were investigated in mice. The relation between delayed type GVHD and suppressor cells was also studied. Bone marrow cells (1 x 10(5)-1 x 10(7) cells) from CBA/N mice were transplanted to lethally irradiated (10 Gy) C57BL/6 mice, and the same type of transplantation was performed in other mice that underwent splenectomy.

Bone marrow from cadaver donors for transplantation.

To determine the feasibility of obtaining bone marrow cells from cadaver donors for transplantation, marrow cells were prepared from 17 cadaver donors. After surgical removal of the iliac crest, as many as 2 X 10(9) cells were isolated. Cadaver marrow had a lower percentage of T cells (mean of 10%) than did marrow from living donors.