The effects of gabapentin and pregabalin on fracture healing: A histological, radiological, and biomechanical analysis.

Objectives: This study evaluated the impact of different doses of gabapentin and pregabalin on fracture healing in a rat femoral shaft model, with histological, radiological, and biomechanical assessments.

Materials And Methods: Seventy male Wistar albino rats were divided into five groups: control, low-dose gabapentin (GBP-L, 300 mg/day), high-dose gabapentin (GBP-H, 3600 mg/day), low-dose pregabalin (PRG-L, 150 mg/day), and high-dose pregabalin (PRG-H, 600 mg/day), based on human equivalent doses. Bilateral femoral fractures were induced; the right femurs were prepared for radiological examination using microtomography, followed by histological analysis, whereas the left femurs were allocated for biomechanical testing.

Development of three biofuel CRMs for the quality parameters in biodiesel and wood pellet via a joint research project.

Biomass is a key element in biofuels which can be defined as a fuel produced through contemporary biological processes, and its increased use can support the EU's aims of reducing greenhouse gas emissions. Information on the nature and the quality of the biomass or biofuel is important in order to support the optimization of their combustion with respect to realizing higher efficiencies and lower emissions during energy production. Three reference materials were produced by a collaborative approach among national metrology institutes and designated institutes within the scope of the EMPIR project: BIOFMET.

Examination of the effect of treatment of severe early childhood caries and fluoride varnish applications on salivary oxidative stress biomarkers and antioxidants.

Background: Saliva contains a variety of biochemical compounds, including antioxidants, and serves as the body's first line of defense against oxidative stress caused by free radicals. The aim of this study was to investigate the effects of dental treatments on salivary oxidative stress biomarkers in children aged 3-5 years with severe early childhood caries (S-ECC) compared to children without caries.

Method: This study was conducted on 20 children aged 3-5 years with severe early childhood caries (S-ECC) and 20 children without caries.

Fabrication of Oro-Dispersible Sodium Valproate-Loaded Nanofibrous Patches for Immediate Epileptic Innervation.

Epilepsy is one of the oldest neurological disorders discovered by mankind. This condition is firmly coupled with unprovoked seizures stimulated by irrepressible neuroelectrical blasts. Orally taken valproate family has been employed for prophylactic management; however, oral administration is not applicable for critical scenarios, thus calling for medication routes fulfilling necessities of immediate innervation.

Prognostic value of the HALP score in metastatic castration-resistant prostate cancer: an analysis combined with time to castration resistance.

Objective: The aim of our study was to assess the impact of the combination of HALP score with TTCR score on OS and PFS in PC patients who developed castration resistance.

Patients And Methods: The study enrolled 152 patients with metastatic disease who had received either ARTAs or docetaxel as first-line treatment. The median cut-off was 30.

Clinical outcomes of selective removal to soft dentin versus firm dentin for deep caries lesions: a randomized controlled trial up to 5 years.

Objectives: This study aimed to compare the success of selective removal to soft dentine (SRSD) with or without calcium silicate (CS) and selective removal to firm dentine (SRFD) in permanent dentition.

Materials And Methods: Between November 2018 and March 2020, 165 posterior deep caries lesions in 134 patients were included in the study and randomly assigned into test (n = 101) and control (n = 64) groups. The control group (n = 46) received the treatment of SRFD with CS, while the test group was further randomized into two groups to receive SRSD with CS (n = 45) and SRSD without CS (n = 45).

Exploring the GSTP1 inhibition potential of photosensitizer compounds for enhanced cancer treatment in photodynamic therapy.

Photodynamic therapy (PDT) has gained considerable attention in cancer treatment due to its non-invasive nature and the ability of photosensitizers to generate reactive oxygen species upon light activation, leading to tumor destruction. Glutathione S-transferase P1 (GSTP1) is a key enzyme in chemotherapy resistance, often overexpressed in various cancers, and its inhibition of GSTP1 presents a promising strategy to enhance cancer treatment. This study is aimed at assessing the potential of prominent photosensitizers as GSTP1 inhibitors through molecular docking analysis to strengthen the efficacy of PDT.

Correction: Invasion Potential of Two Tropical Physalis Species in Arid and Semi-Arid Climates: Effect of Water-Salinity Stress and Soil Types on Growth and Fecundity.

[This corrects the article DOI: 10.1371/journal.pone.

Relationship of stump length with muscle strength, proprioception, and balance in patients with traumatic unilateral transfemoral amputation.

Background: Many factors affect the rehabilitation of lower limb amputation. One of these factors is the length of the stump.

Objective: The aim of this study was to assess the relationship of stump length with muscle strength, proprioception, and balance in patients with traumatic unilateral transfemoral amputation.

The Coexistence of Tinnitus and Temporomandibular Disorder: A Narrative Review on the Importance of an Interdisciplinary Approach.

This review focuses on the coexistence of tinnitus and temporomandibular disorders in terms of epidemiological data, etiology, differential diagnosis, treatment, and interaction between the two disorders. PubMed, Google Scholar, and ClinicalKey digital databases were used to search for publications covering the years 2009-2024. Finally, 77 publications were used.

Association Between Temporomandibular Disorders and Irritable Bowel Syndrome: A Scoping Review.

Temporomandibular disorders (TMDs) encompass various clinical conditions associated with the temporomandibular joint (TMJ) and the masticatory muscles. TMD symptoms include pain in the orofacial region, restricted or altered mandibular movement, and sounds associated with the temporomandibular joint (TMJ). This condition adversely affects quality of life, social functioning, and daily activities, and may also contribute to widespread pain syndromes and comorbidities, including irritable bowel syndrome (IBS).

Enhancing Pain Management and Psychological Recovery in Earthquake Victims: The Role of Continuous Regional Analgesic Techniques Assessed by QoR-15.

Background/objectives: After the earthquakes in Turkey, many citizens were injured, and a long ongoing process requiring physiological and psychological treatments began. The aim of this study was to observe the pain and psychological changes in earthquake victims in light of the QoR-15 score.

Methods: After approval by the local ethics committee (Decision No.

Artificial intelligence for dental implant classification and peri-implant pathology identification in 2D radiographs: A systematic review.

Objective: This systematic review aimed to summarize and evaluate the available information regarding the performance of artificial intelligence on dental implant classification and peri-implant pathology identification in 2D radiographs.

Data Sources: Electronic databases (Medline, Embase, and Cochrane) were searched up to September 2024 for relevant observational studies and both randomized and controlled clinical trials. The search was limited to studies published in English from the last 7 years.

Efficacy of Preoperative Pericapsular Nerve Group Block in Patients with Hip Fracture and its Effect on the Success of Spinal Anaesthesia: A Retrospective Study.

Objective: We intended to research the efficacy of pericapsular nerve group (PENG) block performed with preoperative ultrasonography (USG) in patients who underwent hip fracture repair under spinal anaesthesia and whether it affects the success of spinal anaesthesia.

Methods: The files of 100 patients were analysed, and 60 patients were enrolled in the study. The patients were assigned into two groups: Group P (n = 30) consisted of patients who underwent USG-guided PENG block before the start of surgery and the control group (Group C; n = 30) consisted of patients in whom tramadol infusion was initiated.

Effect of Ultraviolet C light disinfection on the dimensional stability of dental impression materials: A scoping review of the literature.

Background: Ultraviolet C (UVC) light is a physical method proposed for disinfecting dental impression materials and preventing cross-infections in clinical practice. The investigations have focused on the UVC disinfection potential, but little is known about the consequences on dental materials' properties. This scoping review's objective is to evaluate information about the effect of UVC light on the dimensional stability of dental impression materials.

Observation of the distribution of macro-, micro-, and toxic element contents of almond kernels burned with different digestion methods.

In this study, the elemental contents of almonds burned with four different methods to capture the elemental amount of almond kernels in the best way, to increase the release of obtainable elements by decomposing plant tissues, and to make them more atomized were measured and compared with ICP-AES. Depending on the digestion types, the K and Ca contents of almond varieties were determined as 10,167.35 (microwave) and 13,004.

Predicting the risk of cesarean hysterectomy in the management of placenta accreta spectrum disorders: a new model based on clinical findings and ultrasonography.

Purpose: To develop a nomogram to predict the probability of cesarean hysterectomy (CH) in placenta accreta spectrum disorders (PASD) patients.

Methods: Data from 520 patients who underwent surgery with a preliminary diagnosis of PASD at a tertiary center in southeast Turkey between 2013 and 2023 were collected, and 302 patients were included in the study. A predictive model based on clinical and ultrasonographic variables was developed using penalized maximum likelihood estimation (PMLE) regression analysis.

Editorial: A Journal with a Vision into the Evolution of the Dental Profession.

I would like to greet you all as the incoming Editor-in-Chief of the European Journal of Prosthodontics and Restorative Dentistry (EJPRD) which has a history of over 60 years. Back in 1965, the journal was initially named 'Journal (Anglo-Continental Dental Society)' which was published semi-annually by the same society. In 1984, A.

Exploring the Impact of Deleting (or Retaining) a Biased Item: A Procedure Based on Classification Accuracy.

Psychological test scores are commonly used in high-stakes settings to classify individuals. While measurement invariance across groups is necessary for valid and meaningful inferences of group differences, full measurement invariance rarely holds in practice. The classification accuracy analysis framework aims to quantify the degree and practical impact of noninvariance.

Understanding the role of cognitive constructs employed in reading in global math and science achievement.

We utilized PISA-2018 data from 71 countries to investigate the relationship between cognitive constructs employed in reading literacy (locating information, understanding, evaluating and reflecting, single and multiple thinking) and math and science achievement. We found that these cognitive constructs collectively accounted for 56% of the variance in math and 63% in science achievement, even after adjusting for gender, socioeconomic status, and country fixed effects. This means that the majority of cultural differences in math and science achievement (resulting from different education systems) can be explained by cognitive constructs employed in reading.

Photosynthesis and hydrogen energy for sustainability: harnessing the sun for a greener future.

At the dawn of the 21 century, the rapid expansion of manufacturing plants and the widespread destruction of natural habitats significantly contributed to accelerating global warming. This phenomenon has led to severe droughts, irreversible agricultural damage, and substantial challenges in securing food supplies for the burgeoning global population. The alarming surge in atmospheric carbon dioxide concentrations underscores the urgent need to embrace clean energy technologies.

Evaluation of corporate experiences during the accreditation process in the field of health - A qualitative study.

Objective: In our study, we attempted to determine the accreditation process experience of hospital senior managers accredited by the Turkish Health Care Quality and Accreditation Institute (TUSKA). Along with the institutions' accomplishments through the accreditation program, the major challenges they faced during the accreditation process were revealed.

Methods: One of the qualitative research designs used was interpretive phenomenological analysis, which was carried out through semi-structured interviews with hospital senior managers.

High Genetic Diagnostic Yield of Whole Exome Sequencing in Children with Epilepsy and Neurodevelopmental Disorders.

Nowadays, the diagnostic rate of childhood epilepsies is increasing rapidly in parallel with the advances in genetic technology. In this study, it was aimed to reveal the diagnostic yield of whole exome sequencing (WES) in children with epilepsy and neurodevelopmental disorders (NDDs). Children aged 1 to 17 years with epilepsy and NDD who underwent WES were included in this retrospective study.

A Shared Care Model between community and transplant centers facilitates access to allogeneic and autologous transplantation.

Access to allogeneic and autologous hematopoietic stem cell transplantation (SCT) remains inadequate despite its curative potential across hematologic malignancies. In 2015, Hartford HealthCare (HHC) and the Memorial Sloan Kettering Cancer Center (MSK) established the Shared Care Model (SCM) with a primary aim of enhancing SCT access for HHC patients. The SCM comprises several components: an SCT-dedicated nurse-navigator, a health-information exchange for record sharing, telemedicine, and ongoing training of HHC clinicians in transplant patient selection and management.