Natural course of postoperative C-reactive protein and erythrocyte sedimentation rate in unilateral and simultaneous bilateral total knee arthroplasty.

Background: C-reactive protein (CRP) and erythrocyte sedimentation rate (ESR) are valuable markers for detecting periprosthetic joint infection (PJI) post-total knee arthroplasty (TKA). However, their prolonged elevation after TKA diminishes diagnostic reliability. This study investigates CRP and ESR trends in unilateral (U-TKA) and simultaneous bilateral TKA (SB-TKA) patients, comparing their patterns.

Effects of plant-derived antioxidants to the oxidative stability of edible oils under thermal and storage conditions: Benefits, challenges and sustainable solutions.

The stability of edible oils significantly influences their quality, safety, and shelf life. While synthetic antioxidants have traditionally been used, the growing consumer interest in food safety and sustainability has shifted focus towards natural alternatives. Plant-derived antioxidants offer a promising solution, enhancing oxidative stability while meeting clean-label demands.

The impact of COVID-19 pandemic on sarcopenic obesity among children between 6 and 10 years of age: a prospective study.

Unlabelled: This study aims to examine the effects of physical activity, eating habits, sleep patterns, and media use on children's body composition during the COVID-19 pandemic, as well as the relationship of these factors with sarcopenic obesity (SO). This prospective cross-sectional study has involved 431 healthy male and female child participants aged between 6 and 10 years during the COVID-19 pandemic lockdown period. The daily routines of participants, including their dietary habits, levels of physical activity, and media usage patterns, have been assessed.

The Relationship Between Spiritual Care Needs and Death Anxiety in Turkish Patients with Chronic Obstructive Pulmonary Disease.

This study aimed to determine the levels of spiritual care needs and death anxiety, as well as the relationship between them, in Turkish patients with chronic obstructive pulmonary disease (COPD). This descriptive and correlational study included 480 patients who were admitted to the pulmonology outpatient clinics of a public hospital with a diagnosis of COPD between November 1, 2023, and April 31, 2024. The study data were collected using the Patient Diagnosis Form, Dyspnea Fear Level Assessment Form, Spiritual Care Needs Inventory, and Templer Death Anxiety Scale.

Investigation of the effect of a virtual reality-based imagery training model on muscle activation in athletes.

Introduction: In the field of sports psychology, imagery training plays a significant role in enhancing athletes' mental preparation and optimizing sports performance. This study aims to investigate the effects of the Virtual Reality-Based Imagery (VRBI) training model on muscle activation and kinesthetic motor imagery skills in athletes. Specifically, the study compares the VRBI model with traditional imagery methods, including Visual Motor Behavior Practice (VMBP) and Video Modeling (VM), to determine its effectiveness in improving neuromuscular responses.

Potential ability of circulating INSL3 level for the prediction of ovarian reserve and IVF success as a novel theca cell-specific biomarker in women with unexplained infertility and diminished ovarian reserve.

Background: Insulin-like peptide (INSL3), belonging to the insulin-like peptide family, is produced by theca interna cells within antral follicles and the corpora lutea. It is hypothesized that INSL3 is integral to the initial development and function of antral follicles, specifically through its regulatory effect on androgen biosynthesis in the thecal cells of these follicles. Moreover, INSL3 is implicated in the modulation of the ovarian microenvironment, which is essential for facilitating the maturation of oocytes.

Evaluation of the role of thyroid hormones, vitamin B12, vitamin D3, folic acid and ferritin serum levels in pterygium development.

To evaluate the relationship between pterygium and serum thyroid hormone, vitamin B12, vitamin D3, folic acid, and ferritin levels between pterygium patients and control and to assess its correlation with clinical findings. 18-65-year-old 100 pterygium patients and age and sex matched 60 healthy control subjects were included. The peripheric blood sampling results were investigated.

A narrative review of the placebo effect: historical roots, current applications, and emerging insights.

Purpose: Placebo is a term to define physiologically inactive compounds used in treatment that causes physical and emotional changes. The placebo effect, driven by expectation and conditioning, plays a significant role in various conditions like pain, depression, and Parkinson's disease, while the nocebo effect can hinder treatment outcomes. Understanding mechanisms such as neuromodulation and genetics has gained importance in modern medicine.

Noninfectious Uveitis in Pediatric Rheumatology: Long-term Follow-up at Tertiary Centers.

Objectives: Our study aimed to identify potential predictors for additional systemic involvement in patients with noninfectious uveitis, specifically focusing on their demographic, etiological, clinical, and laboratory data features from the pediatric rheumatology perspective.

Methods: Patients with noninfectious uveitis before the age of 18 years and followed up for at least 3 months in 2 tertiary centers of pediatric rheumatology and ophthalmology departments were included in the study. Demographics, etiology, clinical features, laboratory data, and treatments administered were evaluated and compared based on the etiology (idiopathic and systemic disease-related uveitis [SD-U]) and the use of biologic disease-modifying antirheumatic drugs.

Cyclophosphamide treatment with a comparison in both pediatric rheumatology and pediatric nephrology practices.

Background: Cyclophosphamide (CYC) is an inactive alkylating agent that transforms the alkyl radicals into other molecules and is used in combination with systemic corticosteroids in the treatment of many childhood rheumatic diseases, such as systemic lupus erythematosus (SLE), and ANCA-associated vasculitis (AAV). In recent years, rituximab (RTX), a B-cell-targeting anti-CD20 monoclonal antibody, has emerged as a new alternative treatment modality over CYC for induction therapy of childhood-onset rheumatic diseases. Clinicians adopt different practices for using CYC particularly in relation to indications, posology, pre-treatment laboratory work-up, post-treatment follow-up, and screening pre- and post-treatment vaccination status.

Comparison of PDE-5 inhibitors used in erectile dysfunction with some candidate molecules: A study involving molecular docking, ADMET, DFT, biological target, and activity.

Erectile dysfunction (ED) is a urological condition defined as the inability of a man to achieve or maintain an erection. This condition negatively affects his sexual performance and the performance of his partner. Phosphodiesterase type 5 (PDE5) inhibitors are commonly used to treat ED.

Longitudinal Investigation of Brain and Spinal Cord Pericytes After Inducible PDGFRβ Cell Ablation in Adult Mice.

Central nervous system (CNS) pericytes play crucial roles in vascular development and blood-brain barrier maturation during prenatal development, as well as in regulating cerebral blood flow in adults. They have also been implicated in the pathogenesis of numerous neurological disorders. However, the behavior of pericytes in the adult brain after injury remains poorly understood, partly due to limitations in existing pericyte ablation models.

Elexacaftor/Tezacaftor/Ivacaftor Treatment Accessibility and Mental Health: Reducing Anxiety in People With Cystic Fibrosis.

Background: Although modulator therapies have proven effective in cystic fibrosis (CF) access is limited due to reimbursement issues in Turkey. We aimed to examine anxiety and depression levels of people with CF (pwCF) and their caregivers according to their access to modulator treatment.

Methods: Participants genetically eligible for elexacaftor/tezacaftor/ivacaftor (ETI) were divided into Group 1 (access via court decision, not yet on treatment) and Group 2 (unable to access due to reimbursement issues).

Evaluation of SIRT1 Protein Levels and SIRT1/rs7895833 Distributions in Turkish Patients With Obstructive Sleep Apnea.

Objective: Obstructive Sleep Apnea (OSA) is a common heterogeneous sleep disorder that significantly impacts the sleep quality of individuals and leads to severe complications. Patients with OSA often experience disrupted circadian rhythm, hyperactive hypoxia response, and endothelial dysfunction, yet the underlying molecular mechanism remains poorly known. Recent research suggests promising evidence of the potential role of SIRT1 in the etiology of OSA, warranting further investigation.

Common variable immunodeficiency and autoimmune diseases: A 10-year single-center experience.

Objectives: This study aimed to determine the frequency of autoimmune diseases (ADs) accompanying common variable immunodeficiency (CVID) and evaluate clinical and immunological features, organ manifestation, and effects on malignancy and mortality.

Patients And Methods: The retrospective study was conducted with 85 patients (47 males, 38 females; median age: 38 years; range, 30 to 53 years) with CVID between January 2013 and January 2023. The patients were divided into two groups according to the presence of ADs: CVID patients with ADs [AD-CVID (+) group; n=36] and CVID patients without ADs [AD-CVID (-) group; n=49].

MIOS-MFO, a multicenter international observational study of the Lifetech KONAR-MF ventricular septal defect occluder in treating perimembranous ventricular septal defects.

Introduction And Objectives: The Lifetech KONAR-MF ventricular septal defect occluder (MFO) is increasingly used for transcatheter perimembranous ventricular septal defect (pmVSD) closure. We aim to collect real-world data on patient outcomes and MFO performance in pmVSD cases.

Methods: This was a nonrandomized, retrospective, multicenter, postmarketing clinical follow-up study of pmVSD patients implanted with the MFO device between 2018 and 2023.

How should antenatal counseling be given to parents in the fetal corpus callosum agenesis?

Background: We aimed to review the corpus callosum agenesis (CCA) cases diagnosed and managed in our University to contribute to the literature about this antenatally diagnosed fetal cranial anomaly by revealing the antenatal and postnatal outcomes of CCA.

Methods: This retrospective and cross-sectional study examined CCA detected in our clinic between 2012 and 2021. Genetic results, accompanying additional anomalies, termination, and perinatal mortality rates were also calculated.

Enhanced In Vitro and In Vivo Autophagy Suppression via LC3 siRNA-Loaded "Smart" Nanoparticles and Doxorubicin Combination Therapy in Triple Negative Breast Cancer.

Autophagy plays a complex role in cancer progression, serving as both a tumor suppressor and a promoter, depending on the context. In triple-negative breast cancer (TNBC), a particularly aggressive subtype with limited therapeutic options, autophagy inhibition has emerged as a promising strategy to enhance the efficacy of chemotherapy. This study investigates the synergistic effects of autophagy suppression using LC3 siRNA-loaded "smart" nanoparticles (LC3siRNA-NPs) in combination with doxorubicin (DOX) to overcome chemoresistance in TNBC.

Antioxidant capacity, biochemical composition, and mineral composition of leaves in two apple species (Malus domestica Borkh. and M. kirghisorum Al. Fed. & Fed.).

Background: Apple leaves are a rich source of bioactive compounds such as phenolics, flavonoids, and essential minerals, which exhibit significant antioxidant and therapeutic properties. This study focuses on comparing the biochemical composition, antioxidant capacity, and mineral contents of Malus domestica Borkh. cultivars and M.

Echocardiographic Measure of Right Ventricular-pulmonary Arterial Coupling Predicts Survival in Lung Cancer.

Rationale: Echocardiographic indicators of pulmonary hypertension have been reported to predict decreased survival in lung cancer.

Objective: We tested the hypothesis that this may be associated with impaired right ventricular (RV)-systolic pulmonary arterial pressure (sPAP) coupling.

Methods: This prospective observational study included 220 outpatients with non-small cell lung cancer (NSCLC) examined by Doppler, strain, and 3-dimensional echocardiography before starting therapy.

Assessing sleep habits in school-aged children with phenylketonuria: a comparative study.

Phenylketonuria (PKU) is an autosomal recessive metabolic disorder characterized as deficiencies in phenylalanine hydroxylase, leading to neurotoxic effects and neurodevelopmental challenges. Sleep, crucial for cognitive and behavioral development, remains underexplored in PKU populations. This study evaluates sleep characteristics and influencing factors in school-aged children with PKU compared to those with hyperphenylalaninemia (HPA) and healthy controls.

The Effects of Supplemented Coenzyme Q to Extender on the Endoplasmic Reticulum Stress-Related Genes and Sperm Quality Parameters in Cryopreservation of Mouse Spermatozoa.

The endoplasmic reticulum (ER) is the organelle responsible for protein folding in the cell. The damage that may occur during the freezing process of the sperm can exceed the protein loading capacity in the ER. Antioxidants, such as coenzyme Q (CoQ), are added to freezing media to protect sperm cells.

Helicopter parenting and psychological well-being: impact on adolescents' nutrition attitudes.

Background: This study aimed to examine the effect of helicopter parental attitude and psychological well-being level on Attitude towards nutrition in adolescent students.

Methods: This study was designed with the relational-cross-sectional-descriptive model and was conducted with 652 adolescent students studying in a province in eastern Turkey between 16.05 and 10.