The Serum Biomarkers in Ulcerative Colitis.

Objective: In this study, the aim was to evaluate the diagnostic effectiveness of more easily applicable and cost-effective serum biomarkers, such as neutrophil-to-lymphocyte ratio (NLR), platelet-tolymphocyte ratio (PLR), C-reactive protein (CRP) to albumin ratio (CAR), and CRP-to-lymphocyte ratio (CLR), instead of the endoscopic activity index (EAI) used to determine disease activation in ulcerative colitis (UC) patients.

Methods: Blood tests performed during the same period as colonoscopy were reviewed, and NLR, PLR, CAR, and CLR values were calculated. Based on the EAI score, patients with a score <4 were classified as having UC in remission, those with a score ≥4 as having active UC, and those with normal colonoscopy results as the control group.

Brain malformation, neurodevelopmental disorder and epilepsy in a case of two rare genetic diseases: overlapping phenotype.

In most cases there is a single etiological factor causing neuromotor developmental delay and epilepsy while sometimes more than one gene may be involved. These include the autosomal recessive inherited CAMSAP1 gene, which is associated with cortical developmental malformations such as pachygyria and lissencephaly and the autosomal dominant inherited NBEA gene, which plays crucial roles in vesicle trafficking as well as synapse structure and function. Loss of function of both genes together is a well-known disease mechanism.

Are mesenchymal stem cells still effective in acute GvHD management?

Objective: Graft-versus-host disease (GvHD) is a common and serious complication following allogeneic hematopoietic stem cell transplantation (allo-HSCT), significantly impacting transplant efficacy. In the treatment of GvHD, numerous therapeutic approaches have been explored, with mesenchymal stem cells (MSCs) emerging as a prominent immunomodulatory option. We aimed to evaluate efficacy and outcomes of using MSCs for steroid refractory acute GVHD (SR-aGvHD) management.

The role of ruxolitinib in the management of acute GVHD.

Background And Objectives: Following an allogeneic hematopoietic stem cell transplant (allo-HSCT), a primary cause of morbidity and mortality is still steroid-refractory acute graft-versus-host disease (SR-aGVHD). Recently, ruxolitinib, an oral inhibitor of JAK1 and JAK2, was approved for use in individuals suffering from SR-aGVHD. This study aimed to analyze the efficacy and toxicity of ruxolitinib in the real world.

Gender-specific Single Transcript Level Atlas of Vasopressin and its Receptor (AVPR1a) in the Mouse Brain.

Vasopressin (AVP), a nonapeptide synthesized predominantly by magnocellular hypothalamic neurons, is conveyed to the posterior pituitary the pituitary stalk, where AVP is secreted into the circulation. Known to regulate blood pressure and water homeostasis, it also modulates diverse social behaviors, such as pair-bonding, social recognition and cognition in mammals including humans. Importantly, AVP modulates social behaviors in a gender-specific manner, perhaps, due to gender differences in the distribution in the brain of AVP and its main receptor AVPR1a.

What is the role of alpha-1 antitrypsin in the management of acute graft versus host disease?

Objective: Acute graft versus host disease (GVHD) occurs in 20-80 % of patients undergoing allogeneic hematopoietic stem cell transplantation (allo-HSCT). Of these patients, 40 % will be resistant to steroids, which is the standard first-line approach. There is no standard second line treatment approach for patients with steroid refractory acute GVHD (SR-aGVHD).

Is there a relationship between vitamin D levels and graft versus host disease?

Objective: Vitamin D deficiency is common in adult patients undergoing allogenic hematopoietic stem cell transplantation (allo-HSCT). Since vitamin D is an important regulatory factor for the immune system, vitamin D deficiency may have effects on antitumor activity, relapse rates, graft versus host disease (GVHD) occurrence and infection rates in allo-HSCT. We aimed to investigate the effects of vitamin D levels on the outcome of allo-HSCT.

Efficacy of Ruxolitinib in the management of chronic GVHD.

Objectives: Allogeneic hematopoietic stem cell transplantation (allo-HSCT) is a potentially curative treatment for hematological diseases, with success rates improving due to advancements in conditioning regimens and new anti-graft versus host disease (GVHD) drugs. Ruxolitinib, an oral selective Janus kinase (JAK) 1 and 2 inhibitor has been used to mitigate the effects of various inflammatory and myeloproliferative syndromes, given the JAK kinase pathway's central role in cytokine signaling during inflammatory and immune processes. In this study we aimed to assess ruxolitinib's efficacy in patients with chronic GVHD (cGVHD).

Does Illness Perception Predict Hopelessness and Death Anxiety in Palliative Care Patients?

Illness perception is crucial in how patients navigate health challenges. Investigating if it predicts hopelessness and death anxiety is vital, especially in palliative care where these burdens are common. This descriptive, cross-sectional study was conducted with 129 patients receiving treatment in the palliative care clinics of a university hospital.

Effectiveness of ibrutinib in the management of chronic GVHD.

Objectives: Chronic graft-versus-host disease (cGVHD) represents a significant adverse event that may ensue following allogeneic hematopoietic stem cell transplantation (Allo-HSCT). In patients resistant to corticosteroids, which is the first-line treatment for cGVHD, ibrutinib is being evaluated as a potential treatment option. In this study, we aimed to share the findings of our multicenter study regarding the outcomes of ibrutinib treatment in patients with corticosteroid-resistant cGVHD who had previously received multiple systemic therapies.

What should be the optimal dose of post-transplantation cyclophosphamide for GVHD prophylaxis in allogeneic stem cell transplantation?

Objectives: In this study, we aimed to compare the engraftment days, graft versus host disease (GVHD) development, relapse and overall survival (OS) rates in patients using variable intensity conditioning regimens with two different post-transplant cyclophosphamide (PTCy) doses for hematological malignancies.

Material And Methods: We retrospectively analyzed 162 patients who have had PTCy at a dose of 25 mg/kg × 2 and 50 mg/kg × 2 between 2018 and 2024. Patients were divided in 2 groups; PTCy dose with 25 mg/kg × 2 (Group 1, n = 45) and PTCy dose with 50 mg/kg × 2 (Group 2, n = 117).

Immature granulocytes as an early clinical predictor in children with respiratory syncytial virus bronchiolitis.

Background: Immature granulocytes can be measured easily in a complete blood count by new automated hemolytic analyzers and have recently been studied as bio-markers in many infectious/inflammatory diseases. This study aims to investigate whether immature granulocyte percentage (IG%) would enable greater discrimination than conventionally utilized laboratory values in terms of early clinical prediction in instances with respiratory syncytial virus (RSV) bronchiolitis.

Methods: A prospective observational cohort study involved 149 individuals with RSV bronchiolitis.

Only Infant -Rearranged Leukemia Is Susceptible to an Inhibition of Polo-like Kinase 1 (PLK-1) by Volasertib.

-rearranged (r) leukemia is characterized by a poor prognosis. Depending on the cell of origin, it differs in the aggressiveness and therapy response. For instance, in adults, volasertib blocking Polo-like kinase 1 (PLK-1) exhibited limited success.

Reliability and Validity of the Turkish versions of the Davos Assessment of Cognitive Biases Scale (DACOBS) and Cognitive Biases Questionnaire for Psychosis (CBQp).

Introduction: Cognitive biases can be defined as dysfunctional patterns of thought formation that lead to incorrect conclusions and abnormal perceptions and are critical factors in the development and maintenance of psychosis. Two self-report measures assessing cognitive biases in psychosis spectrum disorder (PSD) have recently been developed: the Davos Assessment of Cognitive Biases Scale (DACOBS) and the Cognitive Biases Questionnaire for Psychosis (CBQp). This study aimed to validate the Turkish versions of the DACOBS and CBQp.

Turkish nurses' knowledge, attitudes and practices in the management of incontinence associated dermatitis: A descriptive and cross-sectional study.

Objective: This study aimed to determine nurses' current knowledge, attitudes, and practices in adult intensive care units and palliative care clinics regarding incontinence-associated dermatitis (IAD).

Materials And Methods: This descriptive cross-sectional study was conducted with 355 nurses in adult intensive care and palliative services at two hospitals. Data were collected between 5.

Synergistic enhancement of hydrophobic dental adhesives: autonomous strengthening, polymerization kinetics, and hydrolytic resistance.

The leading cause of composite restoration failure is recurrent marginal decay. The margin between the composite and tooth is initially sealed by a low-viscosity adhesive, but chemical, physical, and mechanical stresses work synergistically and simultaneously to degrade the adhesive, destroying the interfacial seal and providing an ideal environment for bacteria to proliferate. Our group has been developing self-strengthening adhesives with improved chemical and mechanical characteristics.

Multiple life-threatening complications in a patient who received lung transplantation due to cystic fibrosis and their management.

Cystic fibrosis patients may be considered for lung transplantation. Although these patients may experience more successful outcomes and survival rates compared to others, various complications can arise. In particular, infectious complications and septic deaths may be more prevalent in cystic fibrosis patients compared to other lung transplant indications.

Convolutional Neural Networks in the Diagnosis of Cervical Myelopathy.

 Artificial intelligence technologies have been used increasingly in spine surgery as a diagnostic tool. The aim of the present study was to evaluate the effectiveness of the convolutional neural networks in the diagnosis of cervical myelopathy (CM) compared with conventional cervical magnetic resonance imaging (MRI).  This was a cross-sectional descriptive analytical study.

Effect of using a kaleidoscope projector and matching cards on fear and vital signs in children aged 3-6 years receiving inhaled medication.

Aim: The aim of this study was to investigate the effect of the use of projector kaleidoscope and matching card on children's fear and physiological parameters in children aged 3-6 years receiving inhaled medication.

Methods: This randomised controlled study was conducted with the guidelines of Consolidated Standards of Reporting Trials (CONSORT). The sample of children was allocated to the projector kaleidoscope group (n = 38), matching card group (n = 38) and control group (n = 38).

Management of Lacertus syndrome: Perspectives for hand therapists.

Lacertus syndrome presents a diagnostic and therapeutic challenge for hand therapists, requiring a comprehensive understanding of its clinical manifestations, diagnostic considerations and evidence-based therapeutic interventions. The present article aims to provide hand therapists with practical insights into recognizing and treating Lacertus syndrome, highlighting nerve gliding exercises, muscle stretching and ergonomic education. By addressing symptom management and preventive strategies, therapists can help patients relieve lacertus syndrome symptoms, optimize functional outcome and improve occupational status.

Toxic and histopathological effects induced by exposure to the pesticide dicamba in carp Cyprinus carpio L.

This study investigated the effects of dicamba (DIC), a widely used auxinic pesticide in agriculture, on carp fish as an experimental model, especially examining serum adrenocorticotropic hormone (ACTH), cortisol (CORT), growth hormone (GH), and insulin-like growth factor-1 (IGF-1) levels. Additionally, it analyzed serum tumor necrosis factor-α (TNF-α), interleukin-1β (IL-1β), and interleukin-6 (IL-6) levels, as well as histopathological changes in gill and liver tissues. Fish were exposed to varying doses (1.