Publications by authors named "Suematsu H"
() is known to cause intra-abdominal and anaerobic bloodstream infections. However, clinical insights and information on antimicrobial susceptibility in infections are limited. This study aimed to elucidate the clinical characteristics and antimicrobial susceptibility of infections.
View Article and Find Full Text PDFA 15-Year Observational Cohort of Acute Empyema at a Single-Center in Japan.
Antibiotics (Basel)
December 2024
Despite the advancements in diagnostic methods and antibiotic treatment, empyema is a critical respiratory infection, showing a high mortality rate of 10-25%. To evaluate the bacterial etiology and prognostic factors of acute empyema, we conducted this long-term retrospective cohort study at our institute between 2008 and 2022. A total of 80 patients were enrolled in this cohort.
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- The study examines how short-term changes in skeletal muscle and adipose tissue after surgery affect survival and recurrence in gastric cancer patients.
- Patients were analyzed before and one month after surgery, categorizing them based on levels of muscle and fat loss.
- Results indicated that greater loss of adipose tissue correlated with lower survival rates, suggesting that monitoring adipose tissue changes post-surgery could help predict patient outcomes.
Background/aim: Post-gastrectomy lean body mass (LBM) decrease has a significant negative impact on postoperative survival in patients with cancer. This study investigated the effect of intake of at least one-third of the daily protein requirement at breakfast on the maintenance of LBM in patients during the first month post-gastrectomy.
Patients And Methods: Among patients with gastric cancer who underwent curative distal gastrectomy between April 2011 and December 2018, without adjuvant chemotherapy, we evaluated 401 patients who had consumed more than the daily protein requirement in the first month postoperatively, using the FFQW82 nutrition intake questionnaire.
Background/aim: The sex-specific effect of the visceral-to-subcutaneous fat ratio (VSR) before gastrectomy on postoperative survival in patients with gastric cancer (GC) remains unclear. This study measured the preoperative VSR in patients with GC and analyzed its relationship with 5-year overall survival (OS) and relapse-free survival (RFS) by sex.
Patients And Methods: This prospective study included 540 patients with GC undergoing gastrectomy.
Article Synopsis
- - A study was conducted to compare the effectiveness of two ceftriaxone dosages (2 g once-daily vs. 1 g twice-daily) in treating pneumonia in a mouse model specifically for certain bacterial strains.
- - The results showed that the once-daily 2 g regimen was significantly more effective in reducing bacterial counts for strains with minimum inhibitory concentrations (MICs) of 1 and 2 mg/L compared to the twice-daily dosage.
- - However, there was no significant difference in effectiveness between the two regimens against bacteria with a MIC of 4 mg/L.
Introduction: While respiratory syncytial virus (RSV) is one of the most common pathogens in adults admitted to the ICU due to respiratory diseases, no reports regarding the occurrence rate of RSV infections in adults in Japan during the COVID-19 pandemic exist.
Patients And Methods: We conducted this retrospective study to examine the exact occurrence rate of RSV infections in adults. We reviewed all patients (≥18 years) with any respiratory symptoms who received quantitative polymerase chain reaction (PCR) using nasopharyngeal samples for respiratory viruses by GeneLEAD at the Aichi Medical University Hospital between November 2022 and November 2023.
Background/aim: Radical resection after preoperative adjuvant chemotherapy (NAC) is a standard treatment for patients with locally advanced esophageal squamous cell carcinoma (LAESCC), but its outcome remains unsatisfactory. In order to develop a personalized treatment program for LAES, we herein compared the survival prediction utility of five pre-NAC nutritional, inflammatory, and immune indexes in patients with LAESCC.
Patients And Methods: We evaluated the survival of 203 patients with LAESCC who underwent radical resection after NAC from January 2011 to September 2019 for the following representative pre-NAC nutritional, inflammatory, and immune indices: modified Glasgow Prognostic Score, Prognostic Nutritional Index, C-reactive protein/albumin ratio, serum neutrophil/lymphocyte ratio, and Geriatric Nutrition Risk Index (GNRI) were evaluated for their impact on survival.
[Relationship between Serotypes and Biotypes of and the Names of Identified Bacteria in the Microbial Identification and Susceptibility Testing Devices].
Rinsho Biseibutshu Jinsoku Shindan Kenkyukai Shi
December 2023
Article Synopsis
- Yersinia enterocolitica is a bacterium associated with food poisoning, particularly from pork and stream water, and is commonly found in specific serotypes and biotypes in Japan, such as O3 and O8.
- Biotype 3 can show different biochemical characteristics, and a specific strain ([O3, 3, VP-, Suc-]) has been effectively identified using a simple kit, but there is limited information on its identification with other microbial testing devices.
- The study analyzed 15 strains from fecal cultures and found that while certain devices identified them successfully, there remains a chance that [O3, 3, VP-, Suc-] could be misclassified, which should be communicated to healthcare
Background/aim: Radical esophagectomy after preoperative neoadjuvant chemotherapy (NAC) is the standard treatment for locally advanced esophageal squamous cell carcinoma (ESCC). However, careful treatment selection is required when considering organ function in elderly patients. Prealbumin, a rapid turnover protein, is a short-term dynamic nutritional index, and its relationship with long-term postoperative survival in various cancers has been previously reported.
View Article and Find Full Text PDFBackground/aim: Based on gastric shape, patients with gastric cancer can be divided into storage (hook-shaped and ptotic stomach) and reverse outflow (steer-horn and cascade stomach) groups. In patients with gastric cancer, postoperative loss of lean body mass (LBM) is associated with a poor prognosis. This study investigated the influence of preoperative gastric shape on LBM loss 1 month after curative distal gastrectomy.
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- The study focused on patients infected with Fusobacterium spp. in a Japanese hospital from 2014 to 2023, revealing a median patient age of 61 years and a significant proportion of community-acquired infections (84.6%).
- About 25% of patients had solid organ malignancies, with an associated 30-day mortality rate of only 1.3%.
- Resistance to antibiotics like penicillin and moxifloxacin was found, emphasizing the need for careful clinical management of Fusobacterium infections.
β-MoO whiskers prepared by a thermal evaporation method and α-MoO particles were irradiated in a nuclear reactor to produce Mo/Tc radioisotopes via neutron capture. The irradiated targets were then dispersed in water to extract the Mo/Tc isotopes. Of the Mo formed in the β-MoO whiskers, 64.
View Article and Find Full Text PDFTrifluridine/tipiracil (FTD/TPI) is an oral anticancer agent used as a third- or later-line treatment for patients with metastatic gastric cancer/gastroesophageal junction cancer (mGC/GEJC). The C-reactive protein-to-serum albumin ratio (CAR) is an inflammation-based prognostic marker in gastric cancer. This retrospective study evaluated CAR's clinical significance as a prognostic factor in 64 patients with mGC/GEJC administered FTD/TPI as a third- or later-line therapy.
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- The study evaluated the prognostic ability of the TNM8 classification for patients with adenocarcinoma of the esophagogastric junction (AEG), specifically Siewert type II/III, who had curative surgery.
- A total of 138 patients were analyzed, revealing a 5-year overall survival rate of 65.8%, with survival rates decreasing as the clinical stage advanced from I to IV.
- The results indicate that TNM8 clinical staging effectively stratifies survival outcomes for these patients, suggesting its relevance in clinical decision-making.
Article Synopsis
- Irinotecan and FTD/TPI are evaluated as fourth-line treatment options for advanced gastric cancer (AGC) following third-line nivolumab.
- The study involved 137 AGC patients, with 19 receiving irinotecan and 23 receiving FTD/TPI after nivolumab, revealing median overall survival times of approximately 5.83 months for irinotecan and 6.31 months for FTD/TPI.
- Irinotecan showed a higher incidence of all-grade diarrhea, while FTD/TPI had a tendency for greater grade ≥3 neutropenia, suggesting both can be viable, though they come with different safety profiles.
Article Synopsis
- A nationwide surveillance study in Japan assessed the antimicrobial susceptibility of bacterial pathogens related to respiratory tract infections, collecting data from June 2019 to December 2020.
- The study analyzed 932 bacterial strains from 32 medical facilities, finding notable resistance rates, such as 35.3% for methicillin-resistant Staphylococcus aureus and 16.2% for β-lactamase-producing resistant Haemophilus influenzae.
- Results from this surveillance aim to inform treatment strategies for respiratory infections in Japan and promote the responsible use of antimicrobial drugs.
Article Synopsis
- * A newly identified pathogen linked to fungemia has been misidentified in the past, and while recent cases show fever symptoms, the specific causes and clinical aspects remain unclear.
- * A review of 11 treated cases highlighted that echinocandin, an antifungal treatment, was effective for those who received it initially, with a survival rate of 55% among patients with underlying health issues like diabetes or lung cancer.
Preoperative inflammatory and nutritional statuses have potential prognostic effects on patients with gastric cancer (GC) after curative gastrectomy. We investigated the prognostic usefulness of the preoperative neutrophil-to-lymphocyte ratio/albumin ratio (NLR/Alb) in patients with GC. Among 483 patients who underwent gastrectomy for GC, the preoperative prognostic nutritional index (PNI), NLR, and NLR/Alb were calculated using preoperative blood test data.
View Article and Find Full Text PDFBackground/aim: Trifluridine/tipiracil (FTD/TPI) is an anticancer-agent that is administered as third-line or later chemotherapy for metastatic gastric/gastroesophageal junction cancer (mGC/GEJC). Although inflammatory and nutritional statuses have attracted attention as prognostic factors for patients with mGC/GEJC in this therapy, their usefulness has not been fully clarified. Thus, this study investigated the clinical significance of prognostic nutritional index (PNI), neutrophil/lymphocyte ratio (NLR), and NLR/serum albumin (Alb) ratio in patients administered FTD/TPI.
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- A randomized control trial (RCT) is highly valued in Evidence-Based Medicine, but it remains unclear how many patients in real-world settings qualify for participation in these trials.
- The study analyzed patients with infective endocarditis at a single institute from 2007 to 2019, categorizing them into those eligible and ineligible for RCTs, revealing that only 26% of patients met the eligibility criteria.
- The research found significant differences between the two groups, with eligible patients being younger, having fewer health issues, and enjoying better overall survival rates, highlighting that RCTs may not accurately represent the broader patient population.
Background/aim: SEC11A gene encodes the SPC18 protein, which has been implicated in tumour progression by inducing the secretion of various growth factors. We investigated the clinical significance of SEC11A expression in gastric cancer (GC) tissues in patients with locally advanced gastric cancer (LAGC) after curative resection.
Patients And Methods: We estimated SEC11A expression in cancer tissues from 253 pStage II/III GC patients who underwent curative resection using quantitative polymerase chain reaction (PCR) and investigated the relationship of SEC11A expression with clinicopathological factors and survival.
Background/aim: To clarify the clinical significance of measuring the mean corpuscular volume (MCV) of red blood cells before applying neoadjuvant chemotherapy (NAC) in patients with locally advanced esophageal squamous cell carcinoma (ESCC) who will receive NAC followed by curative resection.
Patients And Methods: We retrospectively investigated 169 eligible patients at the Kanagawa Cancer Center between 2011-2018. The patients were divided into high and low-MCV groups.
While acute empyema is a critical infectious disease showing a high mortality rate, there are no prognostic tools to evaluate the disease severity and prognosis for patients. We conducted a retrospective cohort to determine whether quick Sequential Organ Failure Assessment (qSOFA) and SOFA score can predict the disease severity and prognosis of acute empyema. A total of 53 patients were enrolled in the study.
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- Researchers studied the role of epiregulin (EREG) mRNA expression in cancer tissues of 253 gastric cancer patients who had undergone surgery for Stage II/III cancer.
- There was no significant difference in clinical features between high and low EREG mRNA expression groups; however, higher levels of EREG were linked to lower overall survival rates (55% vs. 73% over five years).
- EREG mRNA expression was identified as an independent predictor of poor survival, suggesting it could serve as a valuable prognostic marker following curative surgery.