Publications by authors named "Suely Vieira Da Silva"
Article Synopsis
- * The research analyzed tissue samples from 20 cases of ameloblastoma and 10 dental follicles, employing various techniques like RT-PCR and immunofluorescence to assess the expression levels of the target proteins.
- * Results indicated that ADAMTS-1 was more highly expressed in ameloblastoma, suggesting it could be involved in tumor invasion by degrading the extracellular matrix component versican.
ADAMTSs (A Disintegrin And Metalloproteinase with ThromboSpondin motifs) are secreted proteases dependent on Zn/Ca, involved in physiological and pathological processes and are part of the extracellular matrix (ECM). Here, we investigated if ADAMTS-1 is required for invasion and migration of cells and the possible mechanism involved. In order to test ADAMTS-1's role in ovarian cancer cells (CHO, NIH-OVCAR-3 and ES2) and NIH-3 T3 fibroblasts, we modified the levels of ADAMTS-1 and compared those to parental.
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