Publications by authors named "Suellen Darc Santos Oliveira"
Article Synopsis
- Schistosomiasis causes changes in endothelial cells that promote inflammation and enhance leukocyte adhesion through purinergic signaling.
- Levels of P2Y1 receptors remained similar in infected and control mice, but basal leukocyte adhesion was higher in infected mice, indicating endothelial cell activation.
- Increased expression of NTPDases 2 and 3 in infected mice led to higher ATP hydrolysis and ADP accumulation, which may contribute to the inflammation and complications associated with schistosomiasis.
Schistosomiasis is a chronic inflammatory disease whose macrophages are involved in immunopathology modulation. Although P2X7 receptor signaling plays an important role in inflammatory responses mediated by macrophages, no reports have examined the role of P2X7 receptors in macrophage function during schistosomiasis. Thus, we evaluated P2X7 receptor function in peritoneal macrophages during schistosomiasis using an ATP-induced permeabilization assay and measurements of the intracellular Ca(2+) concentration.
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