Association of genetic variants rs641153 (), rs2230199 (), and rs1410996 () with age-related macular degeneration in a Brazilian population.

This study aimed to investigate the association among genetic variants of the complement pathway R32Q (rs641153), R102G (rs2230199), and (rs1410996) with age-related macular degeneration (AMD) in a sample of the Brazilian population. In a case-control study, 484 AMD patients were classified according to the clinical age-related maculopathy grading system (CARMS) and compared to 479 unrelated controls. The genetic variants rs1410996 of complement H (CFH), rs641153 of complement factor B (CFB), and rs2230199 of complement 3 (C3) were evaluated through polymerase chain reaction (PCR) and direct sequencing.