Comparative study of intravenous opioid consumption in the postoperative period.

Background: Intravenous patient-controlled analgesia (IV PCA) using opiods is an accepted method for delivering postoperative analgesia. The aim of this study was to compare fentanyl and tramadol with IV PCA after spinal anesthesia (SA) and general anesthesia (GA) following cesarean section (C/S).

Methods: Ninety women were randomly assigned to three groups (n=30).

Thrombin activatable fibrinolysis inhibitor and thrombin-antithrombin-III-complex levels in patients with gastric cancer.

The relation between cancer and coagulation is the subject of investigation since a relation between tumor and thrombosis has been determined. Antithrombin III is an important thrombin inhibitor, and increased thrombin-antithrombin (TAT) complex levels activate coagulation. Activated thrombin activatable fibrinolysis inhibitor (TAFI) inhibits the conversion of plasminogen to plasmin.

Increased ischemia-modified albumin levels in patients with gastric cancer.

Reactive oxygen species (ROS) are found in the development stages of carcinogenesis. Fifty two patients with gastric cancer and 35 controls were enrolled in this trial. IMA, MDA, Total Oxidant Status (TOS), Total Antioxidant Status (TAS) and Oxidative Stress Index (OSI) were evaluated.

Might psoriasis be a risk factor for obstructive sleep apnea syndrome?

Background: It is believed that psoriasis is a chronic systemic inflammatory disease. Obstructive sleep apnea syndrome (OSAS) is a disease influencing all systems and characterized by intermittent partial or complete obstruction of the upper respiratory tract during sleep. In our study, we aimed to investigate the frequency of OSAS in patients previously diagnosed with psoriasis in order to investigate a potential association between chronic inflammation psoriasis and OSAS.

Effects of zoledronic acid and ibandronic acid on renal functions and calcium, phosphorus and alkaline phosphatase levels in breast cancer patients with bone metastases: a retrospective analysis.

Aim Of The Study: Bone is a common site of metastasis in patients with breast cancer. Skeletal complications associated with bone metastasis are commonly treated with bisphosphonates. However, there are a number of side-effects associated with these, such as renal failure, hypocalcemia and osteonecrosis of the jaw.

Sensitivity of convex probe endobronchial sonographically guided transbronchial needle aspiration in the diagnosis of granulomatous mediastinal lymphadenitis.

Objectives: The purpose of this study was to investigate the sensitivity and diagnostic value of convex probe endobronchial sonographically guided transbronchial needle aspiration (EBUS-TBNA) in the diagnosis of granulomatous mediastinal lymphadenitis.

Methods: Patients clinically and radiologically suspected to have granulomatous mediastinal disease and followed in our clinic between October 2008 and July 2010 were included. Convex probe EBUS with local anesthesia and under conscious sedation and EBUS-TBNA from hilar and mediastinal lymph nodes were performed after physical examination, chest radiography, computed tomography of the thorax, and routine biochemical analysis.

An alternative management procedure after inadvertent dural puncture.

Background: Accidental dural puncture during epidural blockade is a rare complication. Since postdural puncture headache (PDPH) is the most frequent complication, a wisely management method will also reduce the incidence of PDPH.

Methods: Five patients who had inadvertent dural puncture during the epidural procedure before hip or knee arthroplasty were included in this study.

Neuropsychiatric symptoms, quality of sleep and quality of life in patients diagnosed with nasal septal deviation.

Objectives: This study aims to evaluate the psychiatric symptoms, quality of sleep, quality of life and the predictive factors affecting quality of sleep in patients diagnosed with nasal septal deviation (NSD).

Patients And Methods: Forty male patients (mean age 22.3±1.

Fixed drug eruption against rupatadine fumarate.

Second generation of antihistaminics have better therapeutic efficacy and more predictable pharmacological responses at lower doses than older compounds. However, new compounds have a reduced adverse reaction profile; clinicians can also encounter some unexpected adverse effects of these newer compounds. We report the first case of fixed drug eruption of rupatadine fumarate, which was confirmed by oral provocation test.

Impact of septoplasty on pulmonary artery pressure in patients with markedly deviated septum.

Aim: The nasal septal deviation (NSD) increases upper airway obstruction. This study aimed to measure the mean pulmonary arterial pressure (mPAP) of the patients with markedly deviated nasal septum and to determine the effect of septoplasty on the pulmonary arterial pressure.

Methods: Fifty-one patients with NSD (mean age, 37.

Bilateral breast cancer: a male patient.

Bilateral breast cancer represents less than 2% of male patients with breast cancer. A 63-year old male presented with a mass at right breast and modified radical mastectomy was performed. Pathology was reported as invasive ductal carcinoma.

Clinicopathologic characteristics and BRCA-1/BRCA-2 mutations of Turkish patients with breast cancer.

Background: BRCA-1 and BRCA-2 are two major susceptibility genes for breast cancer. Between 30-70 % of hereditary breast cancers are thought to be attributed to mutations in BRCA-1 or BRCA-2. The aim of our study was to investigate the clinicopathologic characteristics and BRCA mutations of patients with breast cancer living in the northeast region of Turkey.

Effect of α-lipoic acid on sperm quality, reproductive tract measures in thinner exposed rats.

The aim of this study was to investigate the effect of alpha lipoic acid (ALA, an universal antioxidant) on thinner-induced testicular toxicity regarding spermatological features, body and reproductive tract measures in rats. Adult male Sprague-Dawley rats were divided into five treatment groups, eight rats in each. Control group was treated with placebo.

Assessment of cardiac functions using tissue Doppler imaging in children with familial Mediterranean fever.

Objective: Familial Mediterranean fever may carry a potential for cardiovascular disorders because of sustained inflammation during its course; however, there has been a limited number of studies investigating the cardiac functions in children. The aim of this study was to assess both ventricular diastolic functions using conventional echocardiography and tissue Doppler imaging in children with familial Mediterranean fever.

Patients And Methods: The study population included 25 patients with familial Mediterranean fever - mean age was 11.

Basal damage and oxidative DNA damage in children with chronic kidney disease measured by use of the comet assay.

One consequence of chronic kidney disease (CKD) is an elevated risk for cancer. There is sufficient evidence to conclude that there is an increased incidence of at least some cancers in kidney-dialysis patients. Cancer risk after kidney transplantation has mainly been attributed to immunosuppressive therapy.

Cytokine profile in murine toxoplasmosis.

Objective: To investigate which cytokines are produced after acute infection of mice with Toxoplasma gondii (T. Gondii) RH strain.

Methods: Mus domesticus domesticus mice in infected group were inoculated with with highly virulent T.

The effect of prenatal factors on the development of colon cancer.

Background: There is some evidence that prenatal factors can play a role in the development of colon cancer. Children with an old parent age at the time of birth were observed to develop certain childhood cancers more frequently.

Objective: This trial was designed to investigate the effects of some prenatal factors on colon cancer risk.

Micronucleus frequencies in peripheral blood lymphocytes of children with chronic kidney disease.

One of the crucial adverse effects of chronic kidney disease (CKD) and its treatment is an elevated cancer risk. There are no data on cytogenetic effects in children with CKD or children undergoing dialysis or those who have received a transplant. In this study, cytogenetic effects in children with CKD in pre-dialysis (PreD) stage, on regular haemodialysis (HD) and transplanted (Tx) compared with a control group of healthy children has been investigated using the cytokinesis-blocked micronucleus (CBMN) assay and fluorescence in situ hybridisation (FISH) combined with CBMN (CBMN-FISH) in peripheral blood lymphocytes.

Chemical synthesis of the third WW domain of TCERG 1 by native chemical ligation.

The human transcription elongation regulator 1 (TCERG1), with its modular architecture of 3 WW and 6 FF domains, inhibits RNA polymerase II elongation through these WW and FF domains, and interacts with pre-mRNA splicing factors such as SF1, U2 snRNP and U2AF. WW domains are known as the smallest naturally occurring, monomeric, triple stranded, anti-parallel β-sheet structures, generally spanning only about 40 amino acids. The first and second WW domains of TCERG1 have been synthesized and successfully applied for screening cellular targets.

[Investigation of BK and JC virus DNA positivities by real-time polymerase chain reaction in the clinical samples of patients with high risk].

Human polyomaviruses, namely BK (BKV) and JC (JCV) viruses are small DNA viruses that cause latent infections worldwide. Primary infections are usually acquired in the early periods of life and are generally asymptomatic. However BKV/JCV infections may cause severe clinical conditions in immunosuppressive patients such as bone marrow and solid organ transplantation or cancer patients.

Bolus fluorouracil induced syncope and pulseless ventricular tachycardia: a case report.

5-fluorouracil is an anti-cancer drug commonly used in oncology practice. Typical side effects are myelosupression, nausea, vomiting, diarrhea and stomatitis. Cardiotoxicity is the other toxicity.

Resting metabolic rate and anthropometric measurements in male sleep apnea patients.

Objective: Obstructive Sleep Apnea Syndrome (OSAS) is a common sleep-related breathing disorder. Associations among Apnea-Hypopnea Index (AHI), Resting Metabolic Rate (RMR), body habitus differences, and otorhinolaryngologic abnormality may clarify the characteristics of patients with OSAS. In order to test this hypothesis, we aimed to compare the RMR, Modified Mallampati Scores (MMS), anthropometric measurements and body composition of male OSAS patients with simple snorers and to investigate the association among these parameters.

Penile metastasis from adenocarcinoma of the prostate in a patient with colorectal carcinoma.

Skin metastasis secondary to cancer of the prostate is rare and the prognosis is poor. A 65-year-old male patient diagnosed with metastatic colon carcinoma presented with polyuria and subcutaneous nodular mass on dorsal side of the corpus penis. The serum prostate specific antigen (PSA) level was 111.