Evaluation of the effect of therapeutic plasma exchange on serum cytokine levels in pediatric intensive care unit.

Introduction: Therapeutic plasma exchange (TPE) is crucial for saving lives when used appropriately. This study aimed to assess TPE's impact on tumor necrosis factor-like weak inducer of apoptosis (TWEAK) protein and IL-6 levels in critically ill pediatric patients.

Methods: Conducted between May 2022 and December 2022, the study observed pediatric intensive care unit (PICU) patients undergoing TPE, recording demographics, lab results, TWEAK, and IL-6 levels pre- and post-procedure.

Determination of the relationship between frailty level and quality of life in elderly individuals with type 2 diabetes.

The aim of the study was to examine the relationship between frailty level and quality of life in elderly individuals with Type 2 diabetes. This descriptive and correlational study was conducted with 211 patients who applied to the diabetes outpatient clinic of a private and a public hospital in Istanbul between September and November 2022. The data were obtained by using the Personal Information Form, Edmonton Frail Scale and the Quality of Life in the Elderly Scale.

Assessment of in vitro interactions between delafloxacin and other antimicrobials against multi-drug resistant strains.

Novel therapeutic interventions are required to address the critical antimicrobial resistance caused by multidrug-resistant (MDR-PA) infections. This study examines the impact of combining delafloxacin with antibiotics on MDR-PA isolated from various samples. The minimum inhibitory concentrations (MICs) of delafloxacin, alone and in combination with other antibiotics, were determined against forty distinct MDR-PA isolates using the broth microdilution method.

Evaluation of ChatGPT-4o's answers to questions about hip arthroscopy from the patient perspective.

Objectives: This study aimed to evaluate the responses provided by ChatGPT-4o to the most frequently asked questions by patients regarding hip arthroscopy.

Materials And Methods: In this cross-sectional survey study, a new Google account without a search history was created to determine the 20 most frequently asked questions about hip arthroscopy via Google. These questions were asked to a new ChatGPT-4o account on June 1, 2024, and the responses were recorded.

The relationship between the hidden curriculum and fourth-year nursing students' career plans, professional values, and professional readiness: A cross-sectional correlational study.

Objectives: This cross-sectional correlational study investigated the relationship between a hidden curriculum and fourth-year nursing students' career plans, professional values, and professional readiness.

Background: The hidden nursing education curriculum can influence professional outcomes. While nursing curriculum is designed to prepare students to become proficient nurses, the hidden curriculum is linked to unintended learning outcomes.

Predictive value of NT-proBNP for major adverse cardiovascular events within a 6-month period in patients with acute coronary syndrome.

Background: The role of NT-proBNP as a cardiac biomarker for predicting short-term major adverse cardiovascular events (MACEs) in acute coronary syndrome (ACS) remains unclear.

Aims: This study investigated the utility of the NT-proBNP level for predicting MACEs within a 6-month period in patients with ACS.

Methods: This prospective study included 241 consecutively enrolled adults with ACS between September 2023 and February 2024.

Agronomic biofortification of genetically biofortified wheat genotypes with zinc, selenium, iodine, and iron under field conditions.

Inherently low concentrations of zinc (Zn), iron (Fe), iodine (I), and selenium (Se) in wheat ( L.) grains represent a major cause of micronutrient malnutrition (hidden hunger) in human populations. Genetic biofortification represents a highly useful solution to this problem.

Comparison of diagnoses made by dentistry students and by artificial intelligence dentists.

Objectives: The introduction of artificial intelligence (AI) about great changes in the field of dentistry, but it has not yet been fully determined in which areas it will make a positive contribution to dentistry students. The objective of our study was to compare the diagnostic accuracy of undergraduate students (fourth-year dentistry students [4DS] and final-year dentistry students [5DS]) and AI when examining panoramic radiographs.

Methods: Fifty panoramic radiographs and 1602 teeth were examined by 50 4DS who had not received a clinical practice internship, 50 5DS, and an AI application.

Relationship between serum levels of ANGPTL8, Apo C2, and human placental lactogen (hPL) in patients with gestational diabetes mellitus: Interaction of LPL regulators with hPL, a possible contributing factor to insulin resistance.

Introduction: Gestational diabetes mellitus (GDM) is defined as glucose intolerance during pregnancy. We aimed to investigate the potential effects of betatrophin and ApoC2 in GDM, focusing on their roles in LPL (lipoprotein lipase) regulation and their relationship with hPL to elucidate the possible impact of hPL on lipid metabolism and its potential contribution to the development of GDM.

Methods: Thirty pregnant women with normal glucose tolerance and 29 with gestational diabetes mellitus (diagnosed by 75g OGTT between 24 and 28 weeks) were included in the study.

Performance and durability of additively and subtractively manufactured resin-based onlay restorations after thermomechanical aging.

Purpose: To evaluate the effect of material type on dimensional stability, occlusal surface wear, fracture resistance, and failure behavior of resin-based onlay restorations.

Material And Methods: A mandibular right first molar typodont was prepared and digitized using an intraoral scanner to virtually design an onlay restoration with the minimum occlusal thickness of 1.5 mm.

The effect of an escape room game on students' academic self-efficacy and motivation for critical thinking: oncology nursing course.

Objective: This study investigated the effect of an escape room game on oncology nursing course students academic self-efficacy and motivation for critical thinking.

Methods: This study adopted a one-group pretest-posttest experimental research design. The sample consisted of forty-two nursing students.

Associations between airborne algae, ambient air pollution and lung function in a cross-sectional canadian population-based study.

Airborne algae have been associated with respiratory illness in the setting of coastal harmful algae blooms but little is known about their effects in urban populations distributed across a country, and whether ambient air pollution is an effect modifier. Using cross-sectional data from 11,256 participants of the Canadian Health Measures Survey (CHMS), we tested the association between lung function expressed as a forced expiratory volume (FEV) and airborne concentrations of algae measured by a rotation impact sampler in the participant's city of residence on the day of spirometric testing. The daily upper 95th percentiles of algae ranged from 12.

Short-term effectiveness of epidermis dermis fascia kinesiotaping technique in myofascial pain syndrome on upper trapezius: A multi-center, double-blind, randomized clinical study.

Objectives: This study aims to investigate the efficacy of epidermis dermis fascia (EDF) kinesiotaping (KT) technique on pain intensity, number of active trigger points (TrPs), cervical range of motion (ROM) angles, and disability levels in patients with myofascial pain syndrome (MPS) on upper trapezius (UT) muscle.

Patients And Methods: Between January 2019 and January 2020, a total of 180 patients (21 males, 159 females; mean age: 35.9±9.

Impact of scanning interruptions on accuracy of implant-supported full-arch scans: an in-vitro pilot study.

Purpose: To assess the impact of involuntary interruptions (simulating tracking loss by moving the scanner out of its focal distance) and voluntary interruptions (pressing the scanner's turn-on button) on the accuracy of implant-supported full-arch scans using an intraoral scanner (TRIOS 5, version 22.1.10; 3Shape; Copenhagen, Denmark).

DNA methylation-based analysis reveals accelerated epigenetic aging in giant cell-enriched adult-type glioblastoma.

Background: Giant cell (gc)-enriched glioblastoma (gcGB) represents a distinct histological variant of isocitrate dehydrogenase wild-type adult-type glioblastoma with notable enlarged mono- or multinuclear tumor cells. While some studies suggest a survival advantage for gcGB patients, the underlying causes remain elusive. GcGBs are associated with TP53 mutations, and gcs were shown to accumulate DNA double-strand breaks and show deficient mitosis, potentially triggering cellular senescence programs.

Refractory hypoglycemia is sensitive to octreotide therapy: is it triggered by sorafenib or hepatocellular carcinoma?

Hypoglycemia is a medical emergency with a multitude of potential causes. Paraneoplastic hypoglycemia represents a rare cause of this condition. Hepatocellular carcinoma (HCC) can result in paraneoplastic hypoglycemia through extensive tumor infiltration and the presence of insulin-like growth factor 2 precursors.

Breast Cancer Recurrence in Initially Clinically Node-Positive Patients Undergoing Sentinel Lymph Node Biopsy After Neoadjuvant Chemotherapy in the NEOSENTITURK-Trials MF18-02/18-03.

Background: This study aims to identify factors predicting recurrence and unfavorable prognosis in cN+ patients who have undergone sentinel lymph node biopsy (SLNB) following neoadjuvant chemotherapy (NAC).

Methods: The retrospective multi-centre "MF18-02" and the prospective multi-centre cohort registry trial "MF18-03" (NCT04250129) included patients with cT1-4N1-3M0 with SLNB+/- axillary lymph node dissection (ALND) post-NAC.

Results: A total of 2407 cN+ patients, who later achieved cN0 status after NAC and subsequently underwent SLNB, were studied.

Factors influencing the prescription of add-on long-acting muscarinic antagonists in real-world asthma management: Insights from a national registry.

Current guidelines recommend adding long-acting muscarinic antagonists (LAMAs) in patients with uncontrolled asthma, despite the use of moderate to high doses of inhaled steroid-long-acting beta agonists (ICS/LABA). This study aims to analyze the factors related to the prescription of add-on LAMA in clinical practice for asthma patients, shedding light on physicians' preferences. This study included adult asthma patients on add-on LAMA and ICS/LABA monitored for at least one year in a national registry comprising 2053 asthmatics.

Impact of transpedal retrograde wire just marker technique on revascularization of below the knee artery occlusions with ambiguous proximal caps in patients with Buerger's disease.

Background: Chronic total occlusions with ambiguous proximal caps present a significant challenge in endovascular interventions of patients with Buerger's disease.

Objective: We aimed to evaluate the effectiveness of transpedal retrograde wire just marker technique in patients with Buerger's disease presenting proximal cap ambiguity and flush occlusions.

Methods: Seventeen patients with the diagnosis of Buerger's disease who had below the knee artery chronic total occlusions with ambiguous proximal caps were enrolled.

Ameliorative effects of Edaravone against Valproic Acid-Induced kidney damage.

Valproic acid (VPA) is a well-known and increasingly documented antiepileptic drug that has been widely used in the treatment of epilepsy and/or epilepsy-related disorders. Prolonged clinical use of VPA has been reported to cause side effects such as nephrotoxicity. Edaravone (EDA) is a powerful free radical scavenger.