Assessment of the genotoxic potential of the antipsychotic sigma receptor ligand E-5842.

The genotoxic potential of E-5842, a sigma ligand compound being developed as an antipsychotic drug, was evaluated by means of an extensive battery of in vitro and in vivo assays. Negative results were obtained in an Ames test (up to 5000 μg/plate), a mouse lymphoma assay (up to 535.1 μg/ml (-S9) and 891.

A project to modernise the role of the ward manager.

Fractured neck of femur accounted for more than 1.7 million bed days in 2003 (Department of Health, 2003). This article discusses how the role of the ward manager on an older persons' trauma ward was modernised to provide a specialist service for outlying patients while maintaining ward management responsibility.

The use of contemporary MMPI norms in the study of chronic pain patients.

In a previous study, Ahles et al. [1] compared the MMPI results of primary fibromyalgia, rheumatoid arthritis and non-pain control participants. The purpose of the present study was to reanalyze the original data using the contemporary norms of Colligan et al.