Publications by authors named "Sue M Ford"
Cyclosporine A (CsA) is a nephrotoxicant that causes fibrosis via induction of epithelial-mesenchymal transition (EMT). The flavonoid chrysin has been reported to have anti-fibrotic activity and inhibit signaling pathways that are activated during EMT. This study investigated the nephroprotective role of chrysin in the prevention of CsA-induced renal fibrosis and elucidated a mechanism of inhibition against CsA-induced EMT in proximal tubule cells.
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- Cultured kidney cells in high glucose media show increased glycolytic activity, while normal renal proximal tubules use ketone bodies and focus on mitochondrial energy production.
- This study examines how adding the ketone body acetoacetate affects the metabolism of LLC-PK cells, revealing significant increases in various types of respiration and mitochondrial biomarkers.
- Results show that acetoacetate supplementation alters cell metabolism, leading to heightened sensitivity to certain drugs and toxins.
Article Synopsis
- * It was found that LLC-PK cells grown in high glucose (17.5 mM) had significantly lower SGLT activity compared to those in lower glucose concentrations, with SGLT2 identified as the main transporter involved.
- * The decrease in SGLT2 activity was linked to reduced trafficking of the transporter to the cell membrane, influenced by changes in intracellular cAMP and p38 MAPK signaling, which can be reversed with specific treatments.
Toxicology and careers in toxicology, as well as many other scientific disciplines, are undergoing rapid and dramatic changes as new discoveries, technologies, and hazards advance at a blinding rate. There are new and ever increasing demands on toxicologists to keep pace with expanding global economies, highly fluid policy debates, and increasingly complex global threats to public health. These demands must be met with new paradigms for multidisciplinary, technologically complex, and collaborative approaches that require advanced and continuing education in toxicology and associated disciplines.
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