Publications by authors named "Sue K Park"
Background: There are scarce data on risk factors for epithelial ovarian cancer (EOC) in Asian populations. Our goal was to advance knowledge on reproductive -related risk factors for EOC in a large population of Asian women.
Methods: This study used pooled individual data from baseline questionnaires in 11 prospective cohorts (baseline years, 1958-2015) in the Asia Cohort Consortium.
Objective: Active surveillance (AS) has emerged as a viable alternative to immediate surgery for low-risk thyroid cancer. However, several barriers still hinder its widespread adoption and implementation by physicians.
Methods: In 2024, an email survey was conducted among members of the Korea Thyroid Association to assess their perspectives on AS.
Background: The increasing rate of excess body weight (EBW) in the global population has led to growing health concerns, including cancer-related EBW. We aimed to estimate the population attributable fraction (PAF) of cancer incidence and deaths linked to EBW in Korean individuals from 2015 to 2030 and to compare its value with various body mass index cutoffs.
Methods: Levin's formula was used to calculate the PAF; the prevalence rates were computed using the Korean National Health and Nutrition Examination Survey data, while the relative risks of specific cancers related to EBW were estimated based on the results of Korean cohort studies.
Purpose: Population attributable fractions (PAFs) for hormone and reproductive factors have been estimated in several countries. IARC designated as Group 1 and Group 2A carcinogen for hormone factors in breast, ovarian, endometrial and uterine cervix cancer. This study aimed to estimate the PAFs of hormone/reproductive factor attributed to cancer incidence and deaths in Korean women and projected trends from 2015 to 2030.
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- Smoking cessation is crucial for reducing cardiovascular disease and mortality in patients with chronic kidney disease (CKD), but most guidelines are based on general population studies, not specifically CKD patients.
- An analysis of over 66,000 CKD participants found that both former and current smokers had significantly higher risks of atherosclerotic cardiovascular disease (ASCVD) and mortality, with risk increasing based on smoking history and decreasing with longer cessation periods.
- Former smokers with CKD need longer cessation periods (at least 20 years) to diminish risks to levels comparable to never smokers, highlighting the necessity for targeted smoking cessation strategies in this population.
Background: It has been suggested that the association between body mass index and breast cancer risk differs between Asian women and Western women. We aimed to assess the associations between body mass index and breast cancer incidence in East Asian women.
Methods: Pooled analyses were performed using individual participant data of 319,189 women from 13 cohort studies in Japan, Korea, and China.
Background: Mental health affects well-being and physical health. Among adults with chronic kidney disease (CKD), mental health (MH) problems are common and can induce adverse clinical outcomes. We examined the association between patient-reported MH problems and clinical outcomes in adults with non-dialysis CKD.
View Article and Find Full Text PDFPurpose: This study aims to estimate and project the Population Attributable Fraction (PAF) of cancer incidence and death due to carcinogenic drug use in Korea from 2015 to 2030, to estimate the degree of cancer prevention from exposure to carcinogenic drugs in Korea. Selected carcinogenic drugs were immunosuppressive and antineoplastic drugs classified as group I by the International Agency for Research on Cancer (IARC).
Materials And Methods: Systematic review and meta-analyses were conducted to estimate the relative risk (RR) of cancer associated with carcinogenic drug use.
Objectives: To estimate the epidemiologic trends of blindness in patients with diabetic retinopathy (DR) and investigate the age-, period-, and cohort-specific effects on blindness.
Methods: A total of 2.5 million patients with DR aged 20 years or older were included from the Korean National Health Claims database from 2005 to 2019.
Article Synopsis
- * Researchers found that the average age girls start their periods is about 14 years, but it has been getting younger over the past 100 years.
- * Different countries showed different trends, with some like China having ups and downs, while others like Japan and Singapore had a steady decline in the average age.
Article Synopsis
- A study examined the impact of family history of lung cancer (FHLC) on lung cancer incidence and mortality among East Asian individuals, using data from 478,354 participants across 11 cohorts.
- The findings indicated that having a family history of lung cancer increased the risk of developing lung cancer by 45%, affecting both men and women, and regardless of whether individuals were smokers or non-smokers.
- Specific lung cancer types like adenocarcinoma and squamous cell carcinoma showed even higher associated risks, but there was no significant difference in risk based on sex, smoking status, or ethnicity.
Objectives: This study aimed to compare the Delta, Greenland, and Monte Carlo methods for estimating 95% confidence intervals (CIs) of the population-attributable fraction (PAF). The objectives were to identify the optimal method and to determine the influence of primary parameters on PAF calculations.
Methods: A dataset was simulated using hypothetical values for primary parameters (population, relative risk [RR], prevalence, and variance of the beta estimator ) involved in PAF calculations.
Article Synopsis
- The study examines the relationship between body mass index (BMI) and the risks of developing colorectal cancer (CRC) and dying from it in the Asian population, highlighting rising obesity rates and CRC incidence.
- The research pooled data from 17 cohort studies spanning from 1984 to 2002, with a median follow-up of 15.2 years and included nearly 620,000 participants for CRC incidence and over 650,000 for CRC-related mortality.
- Results indicate that higher BMI significantly increases the risk of incident CRC, with greater risks seen for those classified as obese, especially for colon cancer compared to rectal cancer, and a similar pattern was noted for CRC-related deaths.
Background: Chronic kidney disease (CKD) patients are hospitalized for various conditions. Hospitalization increases the readmission rate and mortality rate, seriously deteriorating patients' quality of life. Consequently, it is crucial to analyze the reasons for hospitalization in CKD patients from a broader perspective according to CKD grade.
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- * Analysis of data from over 55,000 breast cancer patients showed that co-observation of variants in BRCA1, BRCA2, and PALB2 with other breast cancer genes occurred less frequently than expected, suggesting a potential correlation with pathogenicity.
- * The findings indicate that identifying a variant of uncertain significance alongside a known pathogenic variant supports evidence against the variant's pathogenicity, which could improve variant classification in clinical settings and for other genetic conditions.
Background: Dietary factors play a role in the etiology of gastrointestinal cancer. We aimed to estimate the burden of gastric and colorectal cancer that can be attributable to dietary factors in adults aged 20 years and older in Korea in 2018.
Methods: Dietary intakes in 2000 were estimated using data from the 2001, 2005, and 2007-2018 Korea National Health and Nutrition Examination Survey (KNHANES).
Objective: This study aimed to assess selenium status in South Korean pregnant women and its impact on maternal thyroid function and pregnancy outcomes.
Methods: 'Ideal Breast Milk (IBM) Cohort Study' included 367 pregnant women out of 442 participants and categorized into three groups based on plasma selenium levels: deficient (< 70 μg/L), suboptimal (70-99 μg/L), and optimal (≥ 100 μg/L). During the second or third trimester, various blood parameters, including selenium, thyroid-stimulating hormone, free T4, free T3, and anti-thyroid peroxidase antibody levels, were measured.
Background: Thyroid cancer (TC) has underwent notable changes in its diagnosis and treatments following the concerns regarding overdiagnosis and overtreatment. However, there is little research on evaluating the effects of these alterations on TC-specific mortality.
Materials And Methods: This population-based cohort study included 434 228 patients with TC using Korean National Health Insurance Service-National Health Information Database.
Background: Evidence suggests a possible link between diabetes and gastric cancer risk, but the findings remain inconclusive, with limited studies in the Asian population. We aimed to assess the impact of diabetes and diabetes duration on the development of gastric cancer overall, by anatomical and histological subtypes.
Methods: A pooled analysis was conducted using 12 prospective studies included in the Asia Cohort Consortium.
Article Synopsis
- High levels of coronary artery calcification (CAC) can lead to serious heart and kidney problems.
- Scientists studied over 1,000 people with chronic kidney disease to see how changes in CAC relate to kidney failure.
- They found that as CAC levels increased, the risk of needing kidney replacement therapy also went up significantly.
Article Synopsis
- A study was conducted using data from 968,738 adults across 20 cohort studies in Asia to investigate the link between diabetes and liver cancer incidence and mortality.
- The findings revealed that adults with diabetes had a significantly higher risk of being diagnosed with liver cancer (hazard ratio of 1.97) and dying from it (adjusted hazard ratio of 1.97) compared to those without diabetes.
- The robust results, supported by a two-stage meta-analysis, contribute valuable evidence to the understanding of liver cancer risks among diabetic populations in Asian countries.
Background: Systematic COronary Risk Evaluation 2 (SCORE2) and SCORE2-Older Persons (OP) models have been proposed as new cardiovascular risk evaluation tools.
Objectives: This study evaluated the performance of SCORE/SCORE-OP and SCORE2/SCORE2-OP in the East Asian population by using population-based cohort data from the National Health Insurance Service (NHIS) Health Screening Cohort of Korea.
Methods: A total of 324,384 NHIS examinees from 2004 to 2005 were divided into 5 age groups: 40-49 years, 50-59 years, 60-69 years,70-79 years, and more than 80 years.
Background: Frailty frequently coexists with hypertension in older patients. We aimed to evaluate the association between frailty and positional change in blood pressure, especially orthostatic hypertension.
Methods: Participants were recruited from 12 University hospitals in South Korea.