3-Dimensional multicellular aggregates of human cervical cancer cell line SiHa - getting to the core of their morphologies.

3-Dimensional (3D) cultures of cancer cell lines exhibit unique morphologies, a feature that can be utilized for understanding several aspects of solid tumors. This study aims to investigate the morphology and morphometrics of agarose hydrogel-induced 3D aggregates of SiHa cell line. Floating 3D aggregates of SiHa cells were obtained using liquid overlay technique on 1 % agarose hydrogel.

Drug resistance in human cancers - Mechanisms and implications.

Cancers have complex etiology and pose a significant impact from the health care perspective apart from the socio-economic implications. The enormity of challenge posed by cancers can be understood from the fact that clinical trials for cancer therapy has yielded minimum potential promises compared to those obtained for other diseases. Surgery, chemotherapy and radiotherapy continue to be the mainstay therapeutic options for cancers.