Publications by authors named "Sudhir R Patel"
Article Synopsis
- Occupational immunization helps keep workers safe by preventing diseases when they work with animals in labs.
- Laboratory animal workers face risks from infections that can spread from animals to humans, so getting vaccines is important.
- The review talks about different diseases, vaccines, how and when to get vaccinated, and also how immunization helps achieve global goals for a healthier world.
Electrocardiographic evaluation is performed in rhesus monkeys to establish the cardiovascular safety of candidate molecules before progressing to clinical trials. These animals are usually immobilized chemically by ketamine (KTM) and tiletamine-zolazepam (TZ) to obtain a steady-state heart rate and to ensure adequate human safety. The present study aimed to evaluate the effect of these anesthetic regimens on different electrocardiographic parameters.
View Article and Find Full Text PDFRhesus monkeys are a non-rodent species employed in the preclinical safety evaluation of pharmaceuticals and biologics. These nonhuman primate species have been increasingly used in biomedical research because of the similarity in their ionic mechanisms of repolarization with humans. Heart rate and QT interval are two primary endpoints in determining the pro-arrhythmic risk of drugs.
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