Publications by authors named "Sudheesh S Nair"
Studies have shown that decorin is a potent pan-cancer tumor suppressor that is under-expressed in most cancers. Decorin interacts with receptor tyrosine kinases and functions as a pan-receptor tyrosine kinase inhibitor, thereby suppressing oncogenic signals. Decorin deficiency promotes epithelial-to-mesenchymal transition and enhances cancer dissemination and metastasis.
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- mTOR is crucial for cell growth and metabolism and is being studied as a potential marker for cancer prognosis in humans and canines.
- In a study of 17 canine skin tumors, 76% showed high or moderate levels of activated p-mTOR, particularly higher in epithelial and melanocytic tumors compared to mesenchymal tumors.
- The results indicate that p-mTOR activation is significant in canine skin tumor development, suggesting a need for further research on mTOR inhibitors as potential treatments.