Publications by authors named "Sudheerkumar P"
Mol Carcinog
February 2008
Article Synopsis
- Tumor associated macrophages (TAMs) play a significant role in gliomas by secreting cytokines that influence tumor functions and contribute to treatment resistance.
- Researchers focused on the Akt and NF-kappaB signaling pathways to investigate their roles in glioma resistance to TNF-alpha-induced cell death using both monolayers and multicellular spheroid models.
- The study found that both Akt and NF-kappaB are activated independently by TNF-alpha and are crucial for promoting resistance to cell death, emphasizing the importance of spheroids as effective models for studying drug resistance mechanisms.
