Publications by authors named "Sudhakar R Jakkaraj"
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Synopsis of recent research by authors named "Sudhakar R Jakkaraj"
- Sudhakar R Jakkaraj's research primarily focuses on the development of novel pharmacological agents for treating conditions such as polycystic kidney disease (PKD) and reversible infertility, emphasizing the exploration of indazole carboxylic acid derivatives and iminosugar compounds.
- His recent findings indicate that the indazole derivative H2-gamendazole shows promise in reducing cyst formation in autosomal dominant polycystic kidney disease (ADPKD) and provides evidence that N-butyldeoxygalactonojirimycin (B-DGJ) can induce reversible infertility in male rats through the inhibition of testicular enzyme activity.
- Jakkaraj's earlier work also included the discovery of potential allosteric binding sites in cyclin-dependent kinases (CDKs), highlighting the need for more selective and effective small molecule inhibitors to address various medical conditions associated with abnormal CDK activity.
