The Golden Age of Thermally Activated Delayed Fluorescence Materials: Design and Exploitation.

Since the seminal report by Adachi and co-workers in 2012, there has been a veritable explosion of interest in the design of thermally activated delayed fluorescence (TADF) compounds, particularly as emitters for organic light-emitting diodes (OLEDs). With rapid advancements and innovation in materials design, the efficiencies of TADF OLEDs for each of the primary color points as well as for white devices now rival those of state-of-the-art phosphorescent emitters. Beyond electroluminescent devices, TADF compounds have also found increasing utility and applications in numerous related fields, from photocatalysis, to sensing, to imaging and beyond.

Characterisation of IBD heterogeneity using serum proteomics: A multicentre study.

Background: Recent genetic and transcriptomic data highlight the need for improved molecular characterisation of inflammatory bowel disease (IBD). Proteomics may advance the delineation of IBD phenotypes since it accounts for post-transcriptional modifications.

Aim: We aimed to assess the IBD spectrum based on inflammatory serum proteins and identify discriminative patterns of underlying biological subtypes across multiple European cohorts.

Perceptions of Lactation Experience Among Neurology Faculty and Impact of Lactation Time on Academic Achievement at U.S. Academic Medical Centers.

To investigate the perceptions of lactation experiences of neurology faculty and the impact of lactation time on academic achievement. This was a cross-sectional study utilizing a survey administered across 19 academic neurology centers in the United States. Respondents self-identified as having children and answered questions about lactation at work.

Regioisomers containing triarylboron-based motifs as multi-functional photoluminescent materials: from dual-mode delayed emission to pH-switchable room-temperature phosphorescence.

Triarylboron compounds have been established as promising candidates in optoelectronic applications. However, realizing multi-functional properties in triaryl boron-based materials remains challenging. Herein, we present two regioisomers, 1 and 2, designed judiciously by connecting a dimethylamino donor and a dimesitylboryl acceptor at 1,4 and 2,6-positions of the naphthalene spacer, respectively.

Analysis of Faculty Gender and Race in Scholarly Achievements in Academic Neurology.

Intersection of gender and race and/or ethnicity in academic medicine is understudied; we aim to understand these factors in relation to scholarly achievements for neurology faculty. Faculty from 19 US neurology departments completed a survey (2021-2022) to report rank, leadership positions, publications, funded projects, awards, and speaker invitations. Regression analyses examined effects of gender, race, and their intersectionality on these achievements.

Effect on functional outcome of robotic assisted rehabilitation versus conventional rehabilitation in patients with complete spinal cord injury: a prospective comparative study.

Study Design: Prospective Comparative Study.

Objective: This study aims to compare the functional outcomes of Robotic-assisted rehabilitation by Lokomat system Vs. Conventional rehabilitation in participants with Dorsolumbar complete spinal cord injury (SCI).

Healing Assessment of Spinal Tuberculosis: A Systematic Review.

Objective: Deciding the healing end point in spinal tuberculosis (STB) remains a controversial topic. The current systematic review aims to address the controversy existing in the literature to find a comprehensive method to assess healing in STB.

Methods: A thorough literature search was carried out for studies with the assessment of healing parameters in STB.

Thermally activated delayed fluorescence emitters showing wide-range near-infrared piezochromism and their use in deep-red OLEDs.

Organic small molecules exhibiting both thermally activated delayed fluorescence (TADF) and wide-ranging piezochromism (Δ > 150 nm) in the near-infrared region have rarely been reported in the literature. We present three emitters MeTPA-BQ, tBuTPA-BQ and TPPA-BQ based on a hybrid acceptor, benzo[g]quinoxaline-5,10-dione, that emit TADF, having photoluminescence quantum yields, , of 39-42% at photoluminescence (PL) maxima, , of 625-670 nm in 2 wt% doped films in 4,4'-bis(-carbazolyl)-1,1'-biphenyl (CBP). Despite their similar chemical structures, the PL properties in the crystalline states of MeTPA-BQ ( = 735 nm, = 2%) and tBuTPA-BQ ( = 657 nm, = 11%) are significantly different.

Chiral B-N AIEgens: Intense Blue Circularly Polarized Luminescence and Piezochromism.

We present a new class of blue circularly polarized luminescent emitters based on tetraarylaminoborane (TAAB) with considerable dissymmetry factor in the solid state. The chiral pendant 1-phenylethylamine in and imparts chirality to the core chromophore, resulting in circularly polarized luminescence signals ( = 0.8 × 10) with a quantum yield of 33% in the crystalline state.

18-F Fluorodeoxyglucose Positron Emission Tomography/Computed Tomography in a Rare Case of Post-COVID-19 Mucormycosis of Femur.

COVID-19 disease was spread rapidly on a global scale. Corticosteroids were believed to reduce the inflammatory lung injury, however, its side effects include increased secondary infections, immunomodulation, and manifestation of latent diabetes mellitus. The incidence of mucormycosis infection was high in post COVID-19-infected patients.

Azaborine as a Versatile Weak Donor for Thermally Activated Delayed Fluorescence.

Extensive research has been devoted to the development of thermally activated delayed fluorescence emitters, especially those showing pure-blue emission for use in lighting and full-color display applications. Toward that goal, herein we report a novel weak donor, 1,4-azaborine (AZB), with complementary electronic and structural properties compared to the widely used dimethylacridan (DMAC) or carbazole (Cz) donors. Coupled with a triazine acceptor, is the direct structural analogue of the high-performance and well-studied green TADF emitter and has Δ = 0.

New advancements in the management of Neuromyelitis Optica spectrum disease: literature review.

Neuromyelitis Optica spectrum disorder (NMOSD) is a relapsing autoimmune disease of the central nervous system (CNS) where aquaporin-4 water channels are the antigenic target of the disease. The spectrum of the disease involves regions of the CNS where the water channel is widely expressed including the spinal cord, the optic nerve, dorsal medulla, brainstem, and thalamus/hypothalamus. Management of NMOSD includes acute as well as long term treatment.

Implementing best practices on data generation and reporting of assays within the ERA4TB consortium.

Tuberculosis (TB) is the historical leading cause of death by a single infectious agent. The European Regimen Accelerator for Tuberculosis (ERA4TB) is a public-private partnership of 30+ institutions with the objective to progress new anti-TB regimens into the clinic. Thus, robust and replicable results across independent laboratories are essential for reliable interpretation of treatment efficacy.

Nanoparticulate Silica Internalization and Its Effect on the Growth and Yield of Groundnut ( L.).

In recent years, foliar applications of nanoparticles are increasingly being employed in agricultural fields as fertilizers to enhance crop yields. However, limited studies are available on the foliar uptake of nanoscale nutrients and their interaction with plants. In this study, we reported the effects of foliar spray with varied concentrations of nanoscale silica (N-SiO) and bulk tetraethyl orthosilicate (TEOS at 2000 ppm) on the growth and yield of groundnut.

Assessment of serum biotin levels and its association with blood glucose in gestational diabetes mellitus.

Aim: The incidence of gestational diabetes mellitus is increasing worldwide. Biotin is shown to improve glycemic status in diabetes mellitus. We wanted to study whether there is a difference in biotin levels between mothers with and without gestational diabetes mellitus (GDM), association of biotin with blood glucose, and with the outcome of GDM.

Distinct transcriptional signatures in purified circulating immune cells drive heterogeneity in disease location in IBD.

Objective: To infer potential mechanisms driving disease subtypes among patients with inflammatory bowel disease (IBD), we profiled the transcriptome of purified circulating monocytes and CD4 T-cells.

Design: RNA extracted from purified monocytes and CD4 T-cells derived from the peripheral blood of 125 endoscopically active patients with IBD was sequenced using Illumina HiSeq 4000NGS. We used complementary supervised and unsupervised analytical methods to infer gene expression signatures associated with demographic/clinical features.

Deformity Correction with Interbody Fusion Using Lateral versus Posterior Approach in Adult Degenerative Scoliosis: A Systematic Review and Observational Meta-analysis.

This study was designed to systematically review and meta-analyze the functional and radiological outcomes between lateral and posterior approaches in adult degenerative scoliosis (ADS). Both lateral (lumbar, extreme, and oblique) and posterior interbody fusion (posterior lumbar and transforaminal) are used for deformity correction in patients with ADS with unclear comparison in this cohort of patients in the existing literature. A literature search using three electronic databases was performed to identify studies that reported outcomes of lateral (group L) and posterior interbody fusion (group P) in patients with ADS with curves of 10°-40°.

Identification of genomic regions governing moisture and heat stress tolerance employing association mapping in rice (Oryza sativa L.).

Background: Rice crop is damaged extremely by abiotic stress world-wide. The best approach to enhance drought tolerance in rice varieties is to identify and introgress yield QTLs with major effects. The Association mapping approach helps in the identification of genomic regions governing physiological, yield and yield attributes under moisture and heat stress conditions in diverse collections of crop germplasm, based on historic recombination events and linkage disequilibrium across the genome.

Holistic healthcare in inflammatory bowel disease: time for patient-centric approaches?

Inflammatory bowel disease (IBD) is an emerging global disease characterised by chronic inflammation of the gastrointestinal tract. However, IBD is also manifested by several extraintestinal symptoms which, along with the intestinal symptoms, impact on the mental and emotional well-being of patients. Despite therapeutic advancements, only one-third of the diagnosed patients receiving approved medical treatments achieve short-term to medium-term remission.

From 2D Ultrasound to Patient-Specific 3D Surface Models for Interventional Guidance.

Ultrasound exam output of large organs like liver has traditionally been limited to still images or 2D cine loops of key structures, without 3D context. Having 3D context for follow up studies makes ultrasound scanning much easier and for interventional applications such as biopsy. 3D context will reduce wrong sample selection thereby increasing patient comfort.

Benchmarking Self-Supervised Representation Learning from a million Cardiac Ultrasound images.

Supervised deep learning has become defacto standard for most computer vision and machine learning problems including medical imaging. However, the requirement of having high quality annotations on large number of datasets places a huge overhead during model development. Self-supervised learning(SSL) is a paradigm which leverages unlabelled data to derive common-sense knowledge relying on signals present in the data itself for the learning rather than external supervisory signals.